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    Glossary Basal Cell Carcinoma

    most common skin cancer, originating in basal epidermal cells

    Basal Cell Carcinoma (BCC) is the most common type of skin cancer, originating in the basal cells, which are found in the deepest layer of the epidermis. It typically appears as a small, shiny bump or nodule on sun-exposed areas of the skin, such as the face and neck, and is usually caused by long-term exposure to ultraviolet (UV) radiation from the sun or tanning beds. While BCC rarely metastasizes, it can cause significant local damage if not treated promptly.

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    1. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000 · 380 citations
    2. Identification of the cell lineage at the origin of basal cell carcinoma Nature Cell Biology · 2010 · 351 citations
    3. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1 Proceedings of the National Academy of Sciences · 2000 · 333 citations
    4. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations Journal of Clinical Investigation · 2011 · 178 citations
    5. Basal cell carcinoma — molecular biology and potential new therapies Journal of Clinical Investigation · 2012 · 146 citations
    6. Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells Journal of Cutaneous Pathology · 1999 · 133 citations
    7. Keratin expression in basal cell carcinomas British Journal of Dermatology · 1992 · 128 citations
    8. Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma ˜The œoncologist · 2016 · 127 citations
    9. Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle Archives of Dermatological Research · 1999 · 107 citations
    10. A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy Nature · 2018 · 105 citations
    11. Cytokeratin expression in trichoblastic fibroma (small nodular type trichoblastoma), trichoepithelioma and basal cell carcinoma British Journal of Dermatology · 1999 · 87 citations
    12. YAP and TAZ are essential for basal and squamous cell carcinoma initiation EMBO Reports · 2018 · 76 citations
    13. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 65 citations
    14. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice Journal of Clinical Investigation · 2004 · 64 citations
    15. Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened Clinical cancer research · 2011 · 63 citations
    16. AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma Nature Communications · 2020 · 60 citations
    17. Hair follicle differentiation‐specific keratin expression in human basal cell carcinoma Clinical and Experimental Dermatology · 2019 · 45 citations
    18. Analysis of 1,25-Dihydroxyvitamin D3 Receptors (VDR. in Basal Cell Carcinomas ˜The œAmerican journal of pathology · 1999 · 42 citations
    19. Nevus comedonicus syndrome: a case associated with multiple basal cell carcinomas and a rudimentary toe International Journal of Dermatology · 2005 · 38 citations
    20. Biochemical and immunohistochemical analyses of keratin expression in basal cell carcinoma Journal of Dermatological Science · 1998 · 37 citations
    21. Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas Genes & Diseases · 2019 · 31 citations
    22. Managing adverse events associated with vismodegib in the treatment of basal cell carcinoma Future oncology · 2016 · 28 citations
    23. Basal Cell Carcinoma With Matrical Differentiation: Expression of .-catenin and Osteopontin American Journal of Dermatopathology · 2007 · 26 citations
    24. A Review of Hedgehog Inhibitors Sonidegib and Vismodegib for Treatment of Advanced Basal Cell Carcinoma Journal of drugs in dermatology · 2021 · 25 citations
    25. Discrimination between basal cell carcinoma and hair follicles in skin tissue sections by Raman micro-spectroscopy Journal of Molecular Structure · 2010 · 25 citations
    26. Molecular Conversations and the Development of the Hair Follicle and Basal Cell Carcinoma Cancer Prevention Research · 2010 · 21 citations
    27. Basal Cell Carcinoma of the Head and Neck Region: A Retrospective Analysis of Completely Excised 331 Cases Journal of skin cancer · 2014 · 20 citations
    28. Emerging drugs and combination strategies for basal cell carcinoma Expert opinion on emerging drugs · 2014 · 19 citations
    29. High‐frequency (22‐MHz) ultrasound for assessing the depth of basal cell carcinoma invasion Skin Research and Technology · 2021 · 18 citations
    30. Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis Molecular Medicine Reports · 2017 · 18 citations