CD34 and BerEP4 Are Helpful to Distinguish Basaloid Tricholemmoma From Basal Cell Carcinoma

    August 2018 in “ ˜The œAmerican journal of dermatopathology/American journal of dermatopathology ”
    Nicholas Turnbull, Waseem Ghumra, Vivek Mudaliar, Josefa Vella, D. S. A. Sanders, Saleem M. Taibjee, Richard Carr
    TLDR BerEP4 and CD34 staining can help tell apart tricholemmoma from basal cell carcinoma.
    The study investigated the use of immunohistochemical markers CD34 and BerEP4 to differentiate between basaloid tricholemmoma and basal cell carcinoma (BCC). It included 55 tricholemmomas (15 basaloid) and compared their profiles with nodular BCCs. BerEP4 was focally positive in only 7.7% of tricholemmomas but widespread in 90.8% of BCCs. CD34 was expressed in 98.1% of tricholemmomas and negative in all BCCs. EMA staining was not effective for differentiation. The presence of 5 or more Merkel cells was more common in tricholemmomas (40.1%) than in BCCs (4.3%). The study concluded that CD34 and BerEP4 are useful markers for distinguishing between these two conditions.
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