research Phenotypic Variation in Biotinidase Deficiency
Biotinidase deficiency has various symptoms and can be treated with biotin supplements.
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research Tregs: Where We Are and What Comes Next?
The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.
research Tumor Regression Predicts Higher Risk of Sentinel Node Involvement in Thin Cutaneous Melanomas
Shrinking skin cancer increases the chance of cancer in nearby lymph nodes.
research Novel TMEM173 Mutation and the Role of Disease-Modifying Alleles
A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.
research Cyclophosphamide: As Bad as Its Reputation? Long-Term Single Centre Experience of Cyclophosphamide Side Effects in the Treatment of Systemic Autoimmune Diseases
Cyclophosphamide has serious side effects, but long-term follow-up can help manage risks.
research Identifying Molecular Targets for Reverse Aging Using Integrated Network Analysis of Transcriptomic and Epigenomic Changes During Aging
Curcumin may help reverse aging by targeting specific genes.
research Evolving Approaches to Profiling the Microbiome in Skin Disease
New technologies help us better understand how skin microbes affect skin diseases.
research A Patient With Combined Polycystic Ovary Syndrome And Autoimmune Polyglandular Syndrome Type 2
A woman was the first known case to have both polycystic ovary syndrome and autoimmune polyglandular syndrome type 2, suggesting a need to check for both conditions in similar patients.
research Effect of Phlebotomy Versus Oral Contraceptives Containing Cyproterone Acetate on Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial
Blood removal and birth control pills both helped with hormone levels in women with PCOS, but birth control was better for regular periods and blood removal had fewer side effects.
research Eyebrow and Eyelash Alopecia: A Clinical Review
The review shows how to properly diagnose and treat the loss of eyebrow and eyelash hair.
research An Updated Overview of Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) is a hormonal disorder in women that can cause infertility and other health issues, and it may be improved by treatments that increase insulin sensitivity.
research Clinical Experience of Using Angelica Dahurica for Androgenic Alopecia
Angelica Dahurica extract helps reduce hair loss and improve hair growth and scalp condition.
research Advances in Mitochondria-Centered Mechanism Behind the Roles of Androgens and Androgen Receptor in the Regulation of Glucose and Lipid Metabolism
Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.
research Regulation and Dysregulation of Hair Regeneration: Aiming for Clinical Application
Understanding hair growth involves complex factors, and more research is needed to improve treatments for hair loss conditions.
research Case of Alemtuzumab-Related Alopecia Areata Management in Multiple Sclerosis
Systemic corticosteroids might help treat hair loss caused by alemtuzumab in MS patients.
research Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases
Tyrosine kinases are important in skin autoimmune diseases and could be targets for new treatments.
research Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis
Hair follicle stem cells help maintain skin health and could improve skin replacement therapies.
research Biologics in the Management of Childhood Atopic Dermatitis
Biologics, especially Dupilumab, are effective and safe for treating severe childhood eczema.
research A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases
The new topical botanical formulation significantly regrew hair in all five patients without side effects.
research Logic-Based Modeling and Drug Repurposing for the Prediction of Novel Therapeutic Targets and Combination Regimens Against E2F1-Driven Melanoma Progression
Tadalafil and Finasteride may help treat aggressive melanoma.
research Human Regulatory T Cells: Role in Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers
Understanding how Regulatory T Cells work could help create treatments for certain skin diseases and cancers.
research Intrinsic and Extrinsic Factors Associated with Hair Graying and Therapeutic Potential of Plant Extracts and Phytochemicals
Plant extracts may help prevent or reverse hair graying.
research Anti-Amnesia-Like Effect of Pinus Densiflora Extract by Improving Apoptosis and Neuroinflammation in Trimethyltin-Induced ICR Mice
Pinus densiflora extract may help improve memory and reduce brain inflammation.
research Epigenetics of Colorectal Cancer
Colorectal cancer development involves both genetic changes and epigenetic alterations like DNA methylation and microRNA changes.
research Bioengineering the Hair Follicle
Bioengineering can potentially treat hair loss by regenerating hair follicles and cloning hair, but the process is complex and needs more research.
research Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One
Adding a second method to PROTACs could improve cancer treatment.
research Cellular Senescence and Aging in Myotonic Dystrophy
Myotonic Dystrophy may age cells faster, and drugs that target aging could be potential treatments.
research Dietary Patterns, Plasma and Hair Trace Element in Ukrainian Cohort of Adults During COVID-19 Pandemic: A Cross-Sectional Study
Good nutrition and essential trace elements like zinc, selenium, and iron are important for a strong immune system and reducing COVID-19 severity.
research Pathology of Mouse Models of Accelerated Aging
Progeroid mouse models show signs of early aging similar to humans, helping us understand aging better.
research Protein Degradation: Expanding the Toolbox to Restrain Cancer Drug Resistance
Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.