Clinical Dermatoscopical Response of Glycyrrhizinic Acid 0.1% Spray in Treating External Anogenital Warts in HIV Patients: A Case Series

    April 2021 in “ HIV & AIDS Review ”
    Pati Aji Achdiat, Rasmia Rowawi, Hendra Gunawan, Oki Suwarsa, Catherina Jessica Sutantoyo
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    Studysummary This study reported that GA 0.1% spray led to only slight improvement in treating anogenital warts among HIV-positive patients over twelve weeks. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the use of glycyrrhizinic acid (GA) 0.1% spray for treating external anogenital warts (AGW) in two HIV-positive patients, finding limited effectiveness due to their compromised immune systems. Over 12 weeks, patients showed only slight reductions in wart size and number, with dermoscopic analysis indicating some response. The poor therapeutic outcome was linked to low CD4 levels, highlighting the challenges of treating AGW in immunocompromised individuals. The study emphasized the potential of GA and the role of dermoscopy in treatment evaluation, marking the first use of GA in such patients. Further research was suggested to explore the relationship between CD4 levels and treatment efficacy.
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