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This study found that blocking autophagy in Atg7-deficient mouse hair keratinocytes altered the molecular composition of hair shafts by increasing the abundance of proteins involved in protein turnover while keratins remained unchanged, highlighting autophagy's role in reducing non-cytoskeletal protein concentrations in hair.

In this study, researchers found that autophagy is crucial for maintaining the mature protein composition of hair shafts, with its disruption leading to increased levels of various proteins, suggesting potential diagnostic applications for detecting impaired autophagy through hair proteomic analysis.

In this study, blocking autophagy with 3-methyladenine significantly improved the survival of inner ear hair cells in a gentamicin-induced ototoxic mouse model.

This study found that activation of RORA significantly promotes the level of autophagy in rat hair follicle stem cells, suggesting a potential target for research on hair follicle development and treatments for conditions like alopecia.

This study found that patients with alopecia areata had significantly lower serum levels of autophagy-related protein 5, indicating a potential role of dysfunctional autophagy in the disease's pathogenesis.

This study suggests that impaired autophagy may be a potential mechanism contributing to androgenetic alopecia, as observed in miniaturized hair follicles from balding scalps.

This study found that while finasteride alone disturbed protein homeostasis in rat skeletal muscle, resistance exercise appeared to mitigate these effects.

This study found that BMP2 increased PTEN expression and induced autophagy, promoting hair follicle stem cell differentiation in both in vitro models and a mouse wound model.

This study found that Cepharanthine may mitigate doxorubicin-induced senescence by reducing SA-β-Gal activity and restoring autophagy in cell models, offering insights for antiaging drug development.

In this in vitro study, pretreatment with Dead Sea water and saline magnetized water reduced UVB-induced DNA damage and inflammation markers in human keratinocyte cells, primarily through autophagy activation, suggesting potential use in topical products to prevent skin damage from UV exposure.

This study found that treatment with a synthesized autophagy inducer improved skin barrier function and hair damage in dogs with atopic dermatitis or hyperadrenocorticism by reducing pro-inflammatory cytokines.

This review examines regulatory mechanisms of quiescent stem cells in tissue homeostasis, drawing on observations from the intestine and other self-renewing tissues, without presenting new data.

In this study, researchers tested detachable microneedles with chitin derivatives in a mouse model of androgenic alopecia, finding them to induce greater hair regrowth than 5% minoxidil, while also positing these materials as safe and cost-effective alternatives for hair loss treatment.

This study identified 617 differentially expressed genes in cashmere goat hair follicles, which are involved in key biological processes and provide insights into hair follicle development.

This study found that PM2.5 exposure induced oxidative stress in human keratinocytes and mouse skin, causing cellular damage, which was mitigated by the antioxidant N-acetyl cysteine.

This study found that sustained intracellular acidosis in mice was associated with shortened lifespan, early aging signs, and impaired autophagy.

This study investigated age-related changes in female scalp dermal fibroblasts, finding alterations in gene and protein expressions associated with fibrosis and senescence, which could potentially affect hair follicle health and contribute to aging-related hair changes.

This study identified that α-ketobutyrate (α-KB) extends lifespan and improves health markers in Caenorhabditis elegans and aged mice by modulating pyruvate metabolism and activating AMPK pathways, with potential implications for human anti-aging treatments.

This study found that eight weeks of finasteride treatment in rats decreased protein synthesis and increased autophagic degradation in skeletal muscle, while resistance exercise may mitigate these effects.

In this review, researchers discussed the anti-inflammatory and immunomodulatory properties of metformin and hypothesized that its topical application could benefit those with alopecia areata, given its effects on immune pathways, hair regrowth, and autoimmune disease management.

This research explores the potential role of the Stx17 protein in hair pigmentation processes and Alopecia Areata, suggesting possible links to the disease's progression.

This study found that modifying adipose-derived stem cells to overexpress the adhesion protein JAM-A increased the adhesion and resilience of dermal papilla cells in the context of androgenic alopecia, potentially facilitating hair regrowth despite challenges such as damage from dihydrotestosterone and macrophages.

This study found that autophagy is impaired in Birt-Hogg-Dubé syndrome-associated renal tumors and identified that the FLCN protein interacts with key autophagy components regulated by ULK1.

This study found that the natural product Shi-Bi-Man significantly promoted hair regeneration in cynomolgus monkeys, increasing hair follicle number and activation by boosting specific protein markers and interactions in Laminin-related pathways.

This pilot study suggests that autophagy is crucial for anagen maintenance in human hair follicles, and targeting this process may help manage hair growth disorders.

In this study, researchers found that exposure to PM10 significantly increased inflammation and impaired collagen synthesis in human dermal fibroblasts, suggesting PM10 contributes to skin aging through these mechanisms.

The researchers reported that autophagy, a lysosome-dependent degradation mechanism, plays a significant role in the cellular remodeling of keratinocyte differentiation in the skin, affecting the properties of the differentiation products by altering cellular components during this process.

This study found that myristoleic acid promotes dermal papilla cell proliferation and anagen signaling through autophagy, cell cycle progression, and activation of the Wnt/β-catenin and ERK pathways.

This study found that sodium butyrate, a metabolite from the HF microbiome, significantly delayed catagen onset and promoted key physiological processes in cultured human hair follicles.