Pigmentation and Autophagy in Alopecia Areata Pathogenesis

April 2017 in “ Journal of Investigative Dermatology ”

S. Erjavec, A.R. Abdelaziz, Lynn Petukhova, Aakash V. Patel, Angela M. Christiano

alopecia areata autophagy pigmentation Syntaxin17 Stx17 whole genome sequencing AA

TLDR Reduced Stx17 expression may contribute to Alopecia Areata.

The study explored the role of pigmentation and autophagy in the pathogenesis of Alopecia Areata (AA), focusing on the protein Syntaxin17 (Stx17). It was hypothesized that pigmented hairs are preferentially attacked in AA, leading to sudden whitening of hair. Stx17, identified as an AA-associated locus, showed reduced expression in AA patient scalp biopsies and is involved in pigmentation and autophagy. While initial sequencing in 113 patients did not reveal causal variants, whole genome sequencing of 500 patients was underway. The study aimed to further define the roles of Stx17, autophagy, and pigmentation in AA progression.

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in Treatment 2 upvotes 3 years ago

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community Covid (likely) induced alopecia areata - now 2nd round of Covid, what can I expect?

in Treatment 1 upvotes 1 year ago

After experiencing hair loss due to alopecia areata following COVID-19 vaccination and infection, the individual saw improvement with steroid treatments and Olumiant. They paused Olumiant during a second COVID-19 infection and expressed concern about potential hair loss flare-ups.

community Onion Juice - An effective topical treatment for Alopecia Areata 🧬

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