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480-510 / 1000+ resultsresearch Exosomal miR-222-3p derived from dermal papilla cells inhibits melanogenesis in melanocytes by targeting SOX10 in rabbits
This study found that in Rex rabbits, exosomal miR-222-3p from dermal papilla cells suppresses melanogenesis in melanocytes by targeting the SOX10 gene, highlighting a novel mechanism by which exosomes influence melanin production.
research Highlights
In a randomized clinical trial, Robinson et al found that patients with melanoma and their partners could effectively perform skin self-examinations after participating in a 30-minute structured skills training, potentially aiding early detection of additional melanomas.
research In Vitroandin VivoStructure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring
This study identified novel selective androgen receptor modulators with enhanced in vivo pharmacological activity through structure-activity relationship analysis in castrated rats.
research Improving selective androgen receptor modulator discovery and preclinical evaluation
This review discusses current challenges in selective androgen receptor modulator discovery and preclinical evaluation and reports no new results, emphasizing the need for basic research to improve safety and selectivity.
research Polyscias Scutellaria As Natural Plant
This study reports that Polyscias scutellaria exhibits diverse pharmacological activities, including antibacterial, antifungal, anti-inflammatory, antioxidant, and antidiabetic properties, suggesting potential therapeutic uses in various health applications.
research A liquid chromatography/tandem mass spectrometry method for determination of aristolochic acid‐I in rat plasma
This study developed and validated a sensitive liquid chromatography–mass spectrometry method to measure aristolochic acid‐I in rat plasma, successfully applying it to pharmacokinetic research.
research MP24-09 MEN WITH AN IMPROVEMENT IN URINARY SYMPTOMS HAVE A LOWER RISK OF MORTALITY
This study concluded that male patients with improved lower urinary tract symptoms may have a lower risk of death, suggesting a potential benefit of treating symptoms beyond just managing patient discomfort.
research Assessing finasteride-associated sexual dysfunction using the FAERS database
Finasteride and dutasteride increase sexual dysfunction reports.
research Cleave but not leave: Astrotactin proteins in development and disease
This review discusses the role of astrotactins in development and their genetic mutations' links to a variety of human diseases, but reports no new clinical results.
research Athena: Speciality Certificate Examination case for formulation and systemic therapy
The document discusses a special exam case for formulating and using systemic therapy named Athena.
research Fadrozole and finasteride exposures modulate sex steroid- and thyroid hormone-related gene expression in Silurana (Xenopus) tropicalis early larval development
The researchers reported that during early embryogenesis and larval development in Silurana tropicalis, inhibiting steroidogenic enzymes cyp19 and srd5beta affects genes related to thyroid and reproductive systems.
research BH19 ‘JAK in the box?’ Long-term safety concerns with oral Janus kinase inhibitors for alopecia areata
This study reviewed clinical trials on JAK inhibitors for alopecia areata, finding them effective for short-term hair regrowth with a favorable safety profile, but noted limited data on long-term risks like malignancies or cardiovascular events beyond two years.
research A Multi‐Center Clinical Trial to Evaluate the Efficacy of the Next Generation TriHex Technology Antiaging Regimen
This study found that using Alastin Restorative Skin Complex Serum 2.0 with TriHex Technology for 12 weeks significantly improved facial skin hydration, elasticity, and overall quality in individuals with moderate to severe skin aging, with histological evidence showing new collagen and elastin fibers.
research Generation of trichogenic adipose-derived stem cells by expression of three factors
This study observed that adipose-derived stem cells modified with trichogenic factors have similar properties to dermal papilla cells and show enhanced hair regeneration potential compared to unmodified adipose-derived stem cells.
research Cyberspace Chat
This review addresses concerns about finasteride and high-grade prostate cancers but reports no new clinical results.
research SALT Score Cards: Facilitating SALT Score Calculation in Alopecia Areata
This study developed a handheld card to simplify the calculation of the SALT score for assessing alopecia areata severity, noting that while it accelerates the process, formal validation against existing methods is still needed.
research Adverse events associated with aromatase inhibitors: an analysis of real-world datasets and drug-gene interaction network
In this retrospective pharmacovigilance study, researchers analyzed over 7,900 adverse event reports related to aromatase inhibitors, identifying common side effects and toxicological mechanisms to highlight potential safety concerns in treating postmenopausal hormone receptor-positive breast cancer.
research P64 Efficacy of baricitinib in patients with different degrees of severe alopecia areata: 52-week results from BRAVE-AA1 and BRAVE-AA2
In this study, baricitinib showed promising results in improving scalp, eyebrow, and eyelash hair loss in adults with severe and very severe alopecia areata over 52 weeks.
research Erthwellness Discount Code "AVA25" Get 25% Off On All Products!
This document promotes an Erthwellness discount code that offers a 25% reduction on all their natural health products, without presenting any new research findings.
research Effects of Periplaneta americana extracts on the growth and proliferation of cutaneous interstitial cells in cutaneous-wound healing
This study found that Kangfuxin improved cell proliferation, migration, and wound healing in a mouse model of cutaneous injury through the activation of the STAT3 signaling pathway.
research Cutaneous wound healing: canine allogeneic ASC therapy
This study found that treating acute and chronic canine skin wounds with adipose-derived mesenchymal stem cells significantly improved healing and reduced inflammation, suggesting potential benefits for human wound care.
research The development and validation of the hair shedding visual scale for Asian women (HSVS‐A)
This study developed and validated the Hair-Shedding Visual Scale for Asian Women, finding it to be an effective tool for identifying FPHL and TE.
research Engineered TGF-β-Enriched Exosomes Delivered by Dissolving Microneedles for Androgenetic Alopecia Therapy
research Amelioration of psoriasis-like skin lesions by human amniotic mesenchymal stem cells: insights from multiomics profiling in mice
This study found that administering human amniotic mesenchymal stem cells (hAMSCs) in a mouse model of psoriasis improved skin lesions and reduced inflammation-related markers, suggesting potential therapeutic benefit and safety for treating psoriasis, and identified specific gene targets involved in the treatment's mechanism.
research IN-SILICO STUDY OF BIOACTIVE COMPOUNDS OF NATURAL MATERIALS AS A JAK- SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION INHIBITOR FOR ANTI-ALOPECIA
This study predicted that 6-hydroxy genistein, coreximine, and scoulerine from Dadap leaves may act as anti-alopecia agents by interacting with JAK2, but further in-vivo testing is needed.
research The silver locus product (Silv/gp100/Pmel17) as a new tool for the analysis of melanosome transfer in human melanocyte–keratinocyte co‐culture
This study introduced a novel in vitro assay for tracking melanosome transfer between melanocytes and keratinocytes, facilitating the quantification of melanin transfer and supporting the role of filopodia as a conduit.
research HAIR LOSS ASSOCIATED WITH ESCITALOPRAM: DO SSRIs AFFECT MELATONIN AT THE HAIR FOLLICLE?
The antidepressant escitalopram likely caused hair loss in a patient.
research HX109 Herbal Extract Promotes Hair Growth by Regulating Cell Cycle in Hair Follicle Dermal Papilla Cells
This study found that the herbal extract HX109 promoted hair growth in mice by increasing cell viability and enhancing hair regrowth, with the effects increasing as doses rose.
research Topical finasteride: A potential therapeutic option for hidradenitis suppurativa
This study found that the U.S. stock market responded heterogeneously to the latest presidential elections, with positive reactions in the Energy, Financials, and Industrials sectors but poorer performance among firms with better environmental scores.