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This study found that mechanical stress activates a WISP-1/Hedgehog signaling axis that contributes to ligamentum flavum hypertrophy and fibrosis, identifying Hedgehog signaling as a potential therapeutic target.

This study observed that the NOTCH signaling pathway may contribute to the development of fibrosis in systemic sclerosis by affecting epithelial cell changes, and inhibiting this pathway could prevent fibrosis in experimental models.

This study demonstrated that CEP may effectively treat pulmonary fibrosis by inhibiting fibroblast activation through regulating macrophage M2 polarization and decreasing fibrosis-associated factors, suggesting a new avenue for future research in this area.

This study found that androgens downregulate BMP2 in dermal papilla cells, inhibiting hair follicle stem cell differentiation, while BMP2 addition may restore hair lineage differentiation through the Wnt/β-catenin pathway.

In this study, engineered mice with a mutation similar to that in Olmsted syndrome showed progressive hair loss due to impaired inner root sheath keratinocyte differentiation and stem cell exhaustion.

This study found that higher levels of the protein Flii were associated with enhanced hair follicle regeneration and longer hair fibers in a mouse model.

This study developed a new protocol to efficiently produce skin dermal stem cells from human induced pluripotent stem cells, which may aid in treating various skin disorders.

This study found that Wnt5a regulates hair follicle differentiation in mice by mediating epithelial-mesenchymal interactions and influencing dermal papilla cell activities.

This study suggests that seasonal rhythm genes in cashmere goat skin are differentially expressed with changing daylight, potentially affecting hormone transformation and light sensitivity.

This study suggests that Annexin A2 isoform 2 might play a role in regulating the proliferation and growth of dermal papilla cells, potentially impacting the hair follicle growth cycle.

This study found that canine hair follicle stem cells in vitro expressed markers associated with multipotency, suggesting their potential role in the hair cycle.

In this study using rabbits, HA2 hydrogels made from cross-linked hyaluronic acid and polysaccharide promoted wound healing better than other treatments, reducing inflammation and scar formation.

This study found that suppressing Jagged1 in epidermal stem cells disrupted Notch signaling and resulted in poor-quality wound healing, suggesting a potential therapeutic target for improving wound repair.

In this study, the researchers found that vitamin D and calcium signaling in keratinocytes are essential for normal skin regeneration after wounding, with deficiencies significantly delaying wound closure and re-epithelialization in mice.

This study describes how manipulating the actin cytoskeleton, particularly through the gelsolin family proteins, may enhance regenerative healing in mammals, suggesting potential therapeutic pathways for improved wound repair.

Researchers made a cell line that grows quickly and can help with hair growth research.

This study found that extracellular vesicles derived from mesenchymal stem cells and umbilical cord blood plasma enhanced wound healing and reduced scar formation in mice, suggesting their potential as therapeutic agents for skin repair.

In this study, dermal papilla cells from rat vibrissae showed potential for treating CNS injuries by secreting neurotrophic factors and promoting neuronal differentiation more effectively than bone marrow mesenchymal stem cells.

Flutamide-induced hypospadias in rats slows down early wound healing.

In this study, researchers established three specific cell lines from Cashmere goat hair follicles and found that cytokeratin 13 might be a novel biomarker for identifying dermal sheath cells.

In this study, different extracellular matrix types altered growth characteristics of cultured human dermal papillae cells but did not significantly affect their biological function-related characteristics.

This review discusses various stem cell types, methods of obtaining them, their applications, and the potential use of exosomes, but reports no new clinical results.

This study constructed a single-cell atlas of hair follicle cells from yaks and taurine cattle, revealing that differences in WNT signaling within dermal papilla cells may be key to the yak's adaptation to cold environments on the Qinghai-Tibet Plateau.

This study observed that transgenic mice with overexpression of HE4 developed keratitis and severe corneal opacity, suggesting that HE4 may significantly influence keratopathy and inflammatory responses in the eye.

This study developed a validated murine model of hypertrophic scar contraction, demonstrating similarities to human skin and observing graft contraction and tissue characteristics over time.

This study found that stimulating dermal papilla cells with specific adipo-osteogenic factors and growth factors helped maintain their viability and restored their hair-forming activity in vitro.

In this study, researchers investigated the penetration and cellular responses to nanoplastics in human skin models with compromised barriers, finding that nanoplastics can penetrate the skin, accumulate in cells, and trigger inflammatory responses through specific signaling pathways.

This review discusses the anticancer properties of ginseng, including its potential to alleviate chemotherapy side effects, and calls for more research on its mechanisms of action in various cancers.

In this study, researchers observed that dietary vitamin D intake and light exposure play a crucial role in vitamin D metabolism in mice, suggesting similar importance for human health in maintaining optimal vitamin D levels.

This study examined 16 sporadic trichoblastic tumors and found that although one showed malignant transformation, clinical follow-up revealed no residual or metastatic disease. RNA sequencing indicated a high tumor mutational burden and absence of a UV-related signature, helping to distinguish these tumors from similar growths.