Cepharanthine Attenuates Pulmonary Fibrosis via Modulating Macrophage M2 Polarization

September 2024 in “ BMC Pulmonary Medicine ”

Jiaqi Bao, Chang Liu, Huafeng Song, Zheying Mao, Wenxin Qu, Fei Yu, Yifei Shen, Jingjing Jiang, Xi Chen, Ruonan Wang, Qi Wang, Weizhen Chen, Shu‐Fa Zheng, Yu Chen

Studysummary This study demonstrated that CEP may effectively treat pulmonary fibrosis by inhibiting fibroblast activation through regulating macrophage M2 polarization and decreasing fibrosis-associated factors, suggesting a new avenue for future research in this area. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigates the potential of Cepharanthine (CEP) in treating pulmonary fibrosis, highlighting its efficacy in inhibiting fibroblast activation. It reveals a novel mechanism where CEP modulates macrophage M2 polarization, leading to a reduction in the expression of fibrosis-associated factors. These findings suggest a promising new direction for future research into pulmonary fibrosis treatment.

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