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This study found that SMR-2 and SMR-6, analogs of retinoic acid and retinol, were approximately 100 times more toxic than retinoic acid in mice, inducing hypervitaminosis A and affecting various organs and tissues.

In this study, SMR-2 and SMR-6, retinoid analogs, were found to be approximately 100 times more toxic than retinoic acid in male mice, primarily affecting skin, immune, and reproductive systems.

New retinoids are effective for various skin conditions and are being developed to have fewer side effects.

This study observed that minimal doses of the arotinoid RO 13-6298 successfully treated two cases of severe psoriasis and psoriatic arthritis unresponsive to traditional therapies, despite some side effects.

This review discusses recent developments in dermatological treatments for skin conditions such as acne, psoriasis, acute inflammation, and alopecia but reports no new clinical results.

This research outlines how retinoids, compounds based on vitamin A, activate nuclear receptors to influence cellular processes such as differentiation and carcinogenesis, with benefits like anti-inflammatory properties but requiring careful management of dose-dependent side effects.

In this study, researchers found that retinoids might improve lupus nephritis resistant to conventional treatments, but the sample size was too small for significant results, and side effects were noted.

Minoxidil showed a 30% success rate for hair growth in a study, and various skin treatments were effective, but some had limitations or side effects.

This study found that 60% of men with mild to moderate androgenetic alopecia showed improvement after treatment with botanically derived 5AR inhibitors, suggesting these compounds may be effective, though larger trials are needed.

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

In this study, 13-cis-5S*,8S*-epidioxy-5,8-dihydroretinoic acid was found to be significantly more cytotoxic to cancer cell lines than other retinoic acid analogs evaluated.

This review summarizes therapeutic advances reported in English-language literature from December 1987 to December 1988 and states no new clinical results.

This study found that two novel nonsteroidal derivatives inhibited specific enzymes in vitro and in vivo, leading to dihydrotestosterone accumulation in androgen-dependent glands, suggesting potential therapeutic use for mood improvement in the elderly.

This study supports the conclusion that the hormetic dose-response model is the most prevalent and fundamental model in biological and biomedical sciences, applicable to a wide range of clinical conditions.

This case report found that two women developed toxic selenium levels after consuming paradise nuts, resulting in symptoms like massive hair loss and nail discoloration.

This review discusses plant extracts for dermatological use, highlighting evidence that some can reduce edema in chronic venous insufficiency or help treat actinic keratoses, but it reports no new clinical results.

This study found that a herbal hair dye formulated with a 1:2 ratio of henna and indigo successfully colored unpigmented hair dark brown to black, with favorable attributes compared to synthetic dyes.

In this study, the researchers investigated the plant Vitex negundo and its active ingredients, noting that both natural and synthetic derivatives exhibit concentrated biological activity, which may explain the plant's traditional use in treating various ailments such as depression, malaria, and skin diseases.

This case report documents a 31-year-old woman with bullous SLE who showed improvement with high-dose parenteral steroids and dapsone, with ongoing follow-up due to potential kidney involvement.

This review summarizes the chemical composition and pharmacological properties of Teak (Tectona grandis) but presents no new research findings, emphasizing its use in traditional medicine and therapeutic potentials.

This review discusses the nutritional and therapeutic benefits of honey based on its botanical origin, and it reports no new clinical results, instead calling attention to its varied uses and potential health impacts.

This review discusses the formulations, mechanisms, and physiological aspects of hair cosmetics and types, but reports no new results, suggesting a foundation for future hair research.

This study suggests that botanical 5AR inhibitors like Serenoa repens and β-sitosterol may improve symptoms of androgenetic alopecia, with 60% of treated subjects showing improvement compared to placebo.

This study found that compound 3, a tetrahydropyridoindole carboxymethylated at position 5, significantly inhibited sorbitol accumulation in both rat eye lenses and tissues affected by diabetes, indicating its potential as a lead compound for ALR2 inhibition.

In this study, dutasteride treatment in retinitis pigmentosa mice increased photoreceptor survival and reduced glial activation, suggesting it may offer a neuroprotective effect.

This study found that 4-(ethoxycarbophenyl) retinamide (RI) exhibited significantly lower acute, subacute, and chronic toxicity compared to other retinoids in mouse and rat models.

This study suggests that Acrotrema arnottianum, a herb used in traditional medicine, contains biologically active metabolites like squalene and α-Tocopherol. It showed antibacterial effects against Staphylococcus aureus and antifungal properties against Candida albicans, while demonstrating antioxidant activity.

This article reviews different generations of synthetic retinoids for dermatological use, discussing their efficacy and significant side effects, but reports no new clinical results.

This study discusses the potential of topical retinoids, vitamin A derivatives, to improve treatment outcomes for androgenetic alopecia by promoting hair growth through extending the anagen phase and stimulating follicular activity, offering a promising approach when combined with existing therapies.

This study reported that in rat retinas under high pressure, allopregnanolone synthesis increased and helped reduce pressure-induced damage through GABAA receptors, suggesting potential therapeutic use in glaucoma.