Systemic Lupus Erythematosus Presenting With Bullous Lesions, Cutaneous Vasculitis and Laryngeal Ulcerations - A Rare Association
October 2022
in “
International journal of research in dermatology
”
TLDR A woman with lupus had unusual symptoms like blisters, skin inflammation, and throat ulcers, which improved with steroid and dapsone treatment.
A 31-year-old female with systemic lupus erythematosus (SLE) presented with rare complications including bullous lesions in sun-exposed areas, cutaneous vasculitis on palms and soles, and laryngeal ulcerations. She had a history of photosensitivity and hair loss. Laboratory tests revealed significant anemia and high levels of autoantibodies (ANA, anti-ds-DNA, anti-Sm), supporting the diagnosis of SLE. Histopathology and immunofluorescence of a skin biopsy confirmed bullous SLE, characterized by subepidermal blisters with neutrophils. The patient showed a positive response to treatment with high-dose parenteral steroids and dapsone. Due to the high risk of renal involvement, she was referred to a nephrologist for ongoing care.
