A Phase II Trial of Retinoids on Lupus Nephritis in a Single Center

    June 2016 in “ Annals of the rheumatic diseases ”
    Masanori Funauchi, Yuji Nozaki, Koji Kinoshita
    TLDR Retinoids may help treat lupus nephritis and reduce steroid use.
    This Phase II trial investigated the effectiveness and safety of retinoids (ATRA and AM80) in treating lupus nephritis (LN) in 23 patients. ATRA (10 mg/day) was administered to 9 patients, and AM80 (4 mg/day) to 14 patients for 6 months. Results showed that urinary protein levels decreased significantly in the ATRA group and tended to reduce in the AM80 group. Serum albumin levels tended to increase, and anti-double-strand DNA antibody levels tended to decrease in both groups. Adverse reactions led to the discontinuation of AM80 in 6 cases. The study concluded that retinoids might improve LN resistant to conventional therapy and could potentially reduce the required dose of steroids. However, the small sample size limited the statistical significance of the findings.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 123 results

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  732 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Heavy shedding after adding tretinoin (.01%) to minoxidil - 2.5 months

      in Minoxidil  3 upvotes 7 months ago
      After adding tretinoin to minoxidil for hair loss treatment, the user experienced increased shedding and no visible regrowth, despite also using microneedling and ketoconazole shampoo. The user cannot take finasteride due to side effects and is seeking advice on whether to continue with the current routine or modify the use of tretinoin.

      community Sucess story for you guys, pics are 10+ years apart.

      in Progress Pictures  311 upvotes 8 months ago
      A user shared a success story showing hair regrowth over 10 years, attributing it to quitting creatine and taking 0.5mg finasteride. Some commenters were skeptical about creatine's impact, while others inquired about side effects, and the original poster reported no negative effects from finasteride.

    Similar Research

    5 / 1000+ results