A Phase II Trial of Retinoids on Lupus Nephritis in a Single Center

    June 2016 in “ Annals of the rheumatic diseases ”
    Masanori Funauchi, Yuji Nozaki, Koji Kinoshita
    TLDR Retinoids may help treat lupus nephritis and reduce steroid use.
    This Phase II trial investigated the effectiveness and safety of retinoids (ATRA and AM80) in treating lupus nephritis (LN) in 23 patients. ATRA (10 mg/day) was administered to 9 patients, and AM80 (4 mg/day) to 14 patients for 6 months. Results showed that urinary protein levels decreased significantly in the ATRA group and tended to reduce in the AM80 group. Serum albumin levels tended to increase, and anti-double-strand DNA antibody levels tended to decrease in both groups. Adverse reactions led to the discontinuation of AM80 in 6 cases. The study concluded that retinoids might improve LN resistant to conventional therapy and could potentially reduce the required dose of steroids. However, the small sample size limited the statistical significance of the findings.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 154 results

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  734 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Painkillers May Block Minoxidil

      in Research/Science  15 upvotes 3 months ago
      Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 4 months ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 11 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Similar Research

    6 / 1000+ results