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This clinical trial found that topical application of Sandalore® 1% significantly reduced hair shedding and increased hair volume in women with telogen effluvium compared to placebo.

This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.

This study reported that compound 16 (olean-12-en-3beta-ol, cinnamate) from Merremia peltata showed potential as an androgen receptor antagonist, suggesting it may benefit alopecia treatment based on molecular docking and ADME-Tox predictions.

This study found that in a rat model, 14,15-EET may alleviate central poststroke pain by enhancing thalamic inhibition through neurosteroid signaling, potentially outperforming gabapentin in early-stage treatment.

This study reports that 4-(alkylthio)- and 4-(arylthio)-benzonitriles showed moderate sebum reduction as androgen receptor antagonists when applied topically in a validated animal model.

This study identified pantolactam based compounds as effective topical antagonists of the androgen receptor, reducing sebum components in a hamster model.

This study found that the novel IPC analog SIG-1451 may inhibit inflammatory cytokine release in cell-based assays relevant to allergic dermatitis.

Formestane is a preferred second-line treatment for advanced breast cancer in postmenopausal women because it's effective and has fewer side effects.

Finasteride boosts morphine's pain relief, stops tolerance, and reduces withdrawal in rats.

This study found that a combination of spermidin, rutine, and zeaxantine effectively reduced staurosporin-induced apoptosis in cultured hair follicle dermal papilla cells, potentially preventing the regression phase in the hair follicle cycle.

This study uncovered how Staphylococcus hominis transports an odor precursor molecule, potentially leading to new ways to control body odor production in humans.

This study found that hydroxycinnamate derivatives, especially a compound named 10a, effectively inhibited SRD5A1 activity and protein expression in cell assays, suggesting potential for treating androgen-related conditions.

This laboratory study concluded that TRPA1 and TRPV1 channels do not play a role in mechanotransduction processes in slowly adapting type II mechanoreceptors in isolated rat sinus hair follicles.

This study synthesized and evaluated hydroxycinnamate derivatives for their ability to inhibit human SRD5A1, finding that three compounds showed significant inhibitory activity and low cytotoxicity. Compound 10a notably reduced SRD5A1 protein expression in cells, suggesting potential for nonsteroidal treatment of androgen-related conditions.

This study investigated the potential of nutmeg-derived phytochemicals as anti-alopecia agents using molecular docking and simulations, finding that geranylgeraniol exhibited significant binding stability and potential efficacy against androgenetic alopecia comparable to finasteride and superior to minoxidil.

This review discusses the biologically active compounds in Maxillariinae orchids, highlighting 62 semiochemicals with medical potential, but reports no new clinical findings.

Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.

This study found that abietic acid from pine resin more effectively inhibits testosterone 5α-reductase than several plant extracts, suggesting potential for treating androgen-dependent diseases.

In this study, analysis of FDA data revealed a substantial risk of dermatologic adverse events with aromatase inhibitors, especially anastrozole and exemestane, highlighting the importance of dermatologic monitoring during such therapies.

This study reported that a spray containing Origanum marjoram essential oil significantly improved hair regrowth, dermal thickness, weight, and lymphocyte levels in rabbits with cyclophosphamide-induced alopecia, suggesting its potential as a natural alternative for hair loss treatment.

This review discusses the use of terpenes and invasomes as permeation enhancers for transdermal drug delivery, focusing on their potential applications in pharmaceutical formulations, but it reports no new experimental results.

This study used NMR spectroscopy and other techniques to fully assign the proton and 13C spectra of the 5α-reductase inhibitor finasteride.

This study reports on a new semantic annotation approach used to identify substances in MEDLINE abstracts responsible for adverse drug reactions, with promising performance shown by a prototype system.

This study suggests that setipiprant's inhibitory effect on aldose reductase may contribute to its anti-inflammatory properties, adding a possible mechanism beyond its known action on the prostaglandin D2 receptor.

In this study, novel substituted benzoyl benzoic acids and phenylacetic acids were potent and selective inhibitors of human steroid 5alpha-reductase type 2, with one compound showing promising bioavailability in rats for potential clinical evaluation.

In this study, researchers developed a new topical atraric acid formulation, AA-TF#15, which showed a significantly higher drug penetration and increased hair regrowth in mice compared to minoxidil and finasteride treatments, suggesting its potential effectiveness for treating scalp androgenic alopecia.

This study developed and validated a sensitive liquid chromatography–mass spectrometry method to measure aristolochic acid‐I in rat plasma, successfully applying it to pharmacokinetic research.

This study identified that rose, thyme geraniol, palmarosa, and tolu balsam essential oils activate TRPV1, with citronellol and geraniol as newly recognized agonists.