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Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

Scientists at the University of Michigan Medical School successfully created a special compound that can be used to improve imaging of prostate cancer.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

We need better ways to test and understand SARMs to make safer and more effective treatments.

New compounds with carborane showed anti-androgen effects similar to flutamide.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

New treatments targeting androgen receptors show promise for drug-resistant prostate cancer.

The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Bicalutamide may help treat female pattern hair loss.

SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.

Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.

Finasteride and dutasteride are effective in treating male hair loss but can cause sexual side effects and birth defects.

Muscles can make their own androgens, which may help muscle growth.

Thiazole, a sulfur and nitrogen chemical, is useful in creating potential drugs for conditions like seizures, cancer, bacterial infections, tuberculosis, inflammation, malaria, viruses, Alzheimer's, diabetes, and A1-receptor issues.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.