27 citations
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September 2017 in “Journal of Medicinal Food” In this study, researchers found that a polyphenolic extract from Annurca apples, high in procyanidin B2, increased hair growth, density, and keratin content in healthy subjects after 2 months of use, and stimulated keratin biosynthesis in vitro.
2 citations
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November 2019 in “Journal of Medicinal Food”
13 citations
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December 2019 in “Nutrients” In human follicular cells, this study found that an Annurca apple-based dietary supplement may stimulate the production of hair keratins, suggesting potential benefits for hair growth.
November 2019 in “Journal of Medicinal Food”
18 citations
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October 2018 in “Nutrients” This study found that Annurca apple polyphenolic extracts reprogram hair follicle metabolism in mice, enhancing mitochondrial activity and keratin production while inhibiting some metabolic pathways.
May 2024 in “FEBS open bio” In this study, testing Annurca apple extract on human follicle dermal papilla cells indicated its potential to prevent patterned hair loss by reducing oxidative stress and increasing factors involved in hair growth.
11 citations
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November 2022 in “JAMA dermatology” This review suggests that certain nutritional supplements may have a potential role in improving hair loss, though evidence quality varies, and such treatments should be discussed collaboratively between physicians and patients.
19 citations
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November 2018 in “Nutrients” This study reports that polyphenols from Annurca apples may safely promote hair growth and protect against chemotherapy-induced alopecia without interfering with chemotherapy regimens.
January 2024 in “Apple Academic Press eBooks” This source reports that while low vitamin levels are linked to various types of alopecia, the effectiveness of supplements is minimally supported by evidence and other toxicity can occur.
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December 2024 in “Apple Academic Press eBooks” This source highlights the nutraceutical potential of amla, noting its traditional use in Ayurvedic and Unani medicine and its reported benefits, including antidiabetic and cardioprotective properties, which could drive market growth for food and beverage applications.
13 citations
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September 2012 in “Critical Reviews in Food Science and Nutrition” This review discusses the functional and nutraceutical importance of wheat straw, emphasizing its bioactive compounds and potential benefits, and reports no new experimental findings.
February 2024 in “PloS one” This study found that certain nutraceuticals did not interfere with tamoxifen's inhibition of estrogen in breast cancer cells and may enhance its effects, suggesting potential as an adjuvant therapy for hair loss in patients undergoing endocrine therapy.
1 citations
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December 2021 in “Pakistan biomedical journal” This review explores the effectiveness of seed cycling, a modern alternative medicine approach, in treating polycystic ovary syndrome and reports no new clinical results.
September 2023 in “International Research Journal of Modernization in Engineering Technology and Science” This article reviews the growing interest and potential health benefits of nutraceuticals, especially herbal products, highlighting their role in maintaining health, preventing diseases, and improving quality of life, while also discussing developments in nutraceutical research and challenges related to aging skin.
October 2025 in “International Journal For Multidisciplinary Research” This review describes evidence suggesting regular apple consumption may improve cardiovascular health and reduce risks for chronic diseases through antioxidant, anti-inflammatory, and other beneficial effects, particularly when consumed as whole fruits rather than processed forms.
February 2024 in “International Journal of Scientific Research in Science and Technology” This literature review outlines the traditional uses, nutritional composition, and bioactive compounds of pomegranate plants, highlighting their varied pharmacological actions such as antibacterial, antiviral, anticancer, and antioxidant effects, and discusses the peel's chemical composition and toxicology.
2 citations
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March 2022 in “PubMed” This review concludes that oral nutraceuticals like Nutrafol® and Viviscal® modestly promote hair growth in individuals with androgenetic alopecia and might be considered as supplementary treatments.
24 citations
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January 2020 in “International Journal of Molecular Sciences” This review discusses the potential benefits of flavonoid-containing botanicals, such as Panax ginseng, in reducing hair loss and promoting hair growth, but reports no new experimental results.
1 citations
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December 2022 in “Current Issues in Molecular Biology” This study found that orally administered Annurca apple extract improved hair length, thickness, weight, and density in mice, while also increasing the expression of hair growth-related genes and proteins, suggesting potential as a natural treatment for hair loss.
2 citations
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June 2023 in “Food science & nutrition” This review summarizes evidence that apple and apple products may offer protective effects against various health issues, including cardiovascular diseases, cancer, mild cognitive impairment, and skin conditions, due to their phytochemical content and mechanisms like anti-inflammatory and antioxidant actions.
May 2023 in “Journal of Applied Cosmetology” In this randomized controlled trial, researchers found that participants with androgenic alopecia taking an Annurca apple extract supplement showed significant increases in hair density and weight and reduced hair loss compared to a placebo, with good skin and gastrointestinal tolerability over 180 days.
12 citations
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September 2022 in “Foods” This review discusses the potential role of nutraceuticals in preventing and treating COVID-19 and post-COVID syndrome, but reports no new clinical findings; the authors highlight the need for further research.
February 2024 in “Archiv EuroMedica” This review suggests that annurca apple extract, rich in polyphenols, may be a promising alternative for treating baldness, though further research is needed to clearly assess its effectiveness compared to existing treatments.
15 citations
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October 2017 in “Dermatologic Clinics” This abstract discusses advancements in hair transplantation technology, highlighting the role of robotics and follicular unit extraction/grafting in achieving excellent clinical outcomes, with adjuvant treatments like platelet-rich plasma, lasers, and stem cells potentially improving the durability and appearance of results.
November 2025 in “Journal of Neonatal Surgery” This study developed an herbal hair oil containing plant extracts such as Aloe barbadensis and Nigella sativa, reporting it showed good antioxidant and antimicrobial activity, suggesting potential benefits for hair growth and hair fall prevention.
139 citations
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October 1999 in “Environmental Health Perspectives” This article reviews the scientific exploration of Ayurvedic medicinal plants and discusses their modern applications, such as a drug developed from Commiphora wightti for lipid disorders, without reporting new clinical findings.
30 citations
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July 2010 in “Experimental Dermatology” This article reviews the role of polyamines in hair follicle growth and discusses potential therapeutic applications but provides no new clinical results.
24 citations
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October 2022 in “Revista Brasileira de Farmacognosia” This review discusses the pharmacological actions of mangiferin and the potential of delivery carriers to overcome its limitations, but reports no new clinical results.
10 citations
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November 2013 in “African Journal of Traditional Complementary and Alternative Medicines” In this study, herbal hair oils made from Cuscuta reflexa showed effectiveness in promoting hair growth, reducing dandruff, and minimizing hair fall when tested on human volunteers and rats.
6 citations
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April 2019 in “Journal of Cosmetic Dermatology” This review discusses the impact of age-related hair changes on perceived attractiveness and self-perception, emphasizing the need for holistic anti-aging consultations that include hair preservation strategies.