7 citations
,
August 2022 in “Nature communications” This study found that Thy1+ keratinocytes in the basal layer of the interfollicular epidermis play a crucial role in epidermal homeostasis and wound repair, with their ablation impairing these processes.
September 2025 in “Medicine & Science in Sports & Exercise” In this rodent study, the researchers found that different hormone therapies affected gut microbiota and goblet cell counts, with notable microbial shifts observed between groups receiving estrogen with and without an orchiectomy, linked to estrogen metabolism.
48 citations
,
March 1993 in “The Laryngoscope” This study found that EGF receptors are aberrantly regulated and persist in cholesteatoma epithelium, suggesting a hyperproliferative character compared to normal human skin.
122 citations
,
May 2010 in “Plant Physiology” This study found that expressing certain PIN proteins in Arabidopsis root hairs inhibited growth by decreasing auxin levels, while PIN5 slightly stimulated growth, demonstrating differential effects on auxin transport.
4 citations
,
January 2006 in “PubMed” This study found that finasteride-induced DHT deficiency altered estrogen receptor expression in the epididymis, potentially destabilizing its function.
25 citations
,
June 2017 in “Neuropharmacology” This study observed that overexpressing TSPO in the hippocampal dentate gyrus of mice led to significant anxiolytic and antidepressant-like effects, potentially mediated by increased allopregnanolone synthesis.
This study found that inhibiting AP-1 activity in mice can induce lineage transdifferentiation between squamous and sebaceous tumors, suggesting AP-1's role in maintaining tumor cell identity.
January 2020 in “Nihon Yakuri Gakkai nenkai yoshishu” This study suggests that 5α-reductase-mediated metabolism of progesterone contributes to the differentiation of endometrial stromal cells, potentially influencing progesterone levels and promoting cell differentiation.
37 citations
,
January 1997 in “Journal of Pharmaceutical Sciences” This study observed that hairless rat skin was more permeable to mannitol and progesterone than hairy rat skin, indicating that follicular structures significantly impact percutaneous absorption.
180 citations
,
June 2004 in “Journal of Pharmacology and Experimental Therapeutics” This study found that progesterone's antiseizure effects in mice occurred primarily through conversion to allopregnanolone, rather than through the progesterone receptor, as evidenced by results in PR knockout mice.
July 2019 in “Journal of the ASEAN Federation of Endocrine Societies” This case report describes a young woman with an adrenal oncocytic tumor of uncertain malignant potential, highlighting the need for ongoing surveillance due to possible malignancy.
8 citations
,
August 1987 in “The Journal of Dermatology” This study reports that the monoclonal antibody BKN-1 specifically stained basal cell epithelioma cells and certain normal skin structures, indicating a similarity in keratin expression between the tumor and follicular epithelium below the isthmus portion.
January 2023 in “Records of Pharmaceutical and Biomedical Sciences” This review discusses the advantages and properties of mucoadhesive buccal dosage forms and reports no new clinical findings; the authors emphasize the potential of spanlastics as flexible, biodegradable drug carriers.
1 citations
,
September 2017 in “Journal of Investigative Dermatology” The researchers reported that inhibiting 11β-HSD1 activity in human dermal papilla cells may reduce the negative effects of glucocorticoids on hair growth, suggesting potential treatment for stress-related hair loss.
19 citations
,
December 2016 in “PLOS ONE” This study found that proteins secreted by early-passage dermal papilla cells, including SDF1, MMP3, biglycan, and LTBP1, may play significant roles in hair follicle regeneration.
5 citations
,
February 2022 in “Seminars in cell & developmental biology” This review discusses the complexities of hidradenitis suppurativa pathogenesis, highlighting issues with Notch signaling, immune dysregulation, and the role of keratinocytes and ECM, but reports no new clinical results.
May 2018 in “Cell stem cell” This study reports that myoepithelial cells in submucosal glands can act as reserve stem cells, regenerating surface airway epithelium after severe injury through a mechanism involving Sox9 and Wnt signaling.
6 citations
,
June 1976 in “Journal of ultrastructure research” This study identified the presence of recognizable organelles, such as lysosomes and mitochondria, in both the keratinized fiber and the hardened inner root sheath of the Romney wool follicle.
45 citations
,
September 1998 in “Journal of Investigative Dermatology” This study found that sebaceous glands predominantly exhibit oxidative activity of the type 2 17β-hydroxysteroid dehydrogenase isozyme, which is not inhibited by 13-cis retinoic acid.
172 citations
,
March 2019 in “The EMBO Journal” This study found that in Arabidopsis thaliana, the interaction between extracellular leucine-rich repeat extensins and the receptor-like kinase FERONIA helps control vacuolar expansion, crucial for cellular elongation.
June 1995 in “International Journal of Gynecology & Obstetrics” This article discusses immunohistochemical analysis of estrogen and progesterone receptors in endometrium and peritoneal endometriosis, introducing a new quantitative method, but reports no new experimental results.
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study using a genetic mouse model found that S. aureus-driven dysbiosis sustains inflammatory skin side effects from EGFR inhibitors, suggesting prophylactic antibiotic treatment may reduce rash severity without fixing barrier defects.
4 citations
,
May 2023 in “Research Square (Research Square)” This study found that cephalanthine inhibited the growth of gastric cancer cells in vitro and in vivo by inducing oxidative stress and altering energy metabolism, suggesting its potential as a treatment for gastric cancer.
July 2013 in “Pharmaceutical Regulatory Affairs Open Access” Formulation F1 is the best for delivering finasteride effectively.
This literature review reports that mesenchymal stem cell-derived secretome, including conditioned medium and extracellular vesicles, shows promise as an effective treatment for various diseases in animal and human in-vivo models, with ongoing clinical trials and recommendations for future research discussed.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that early-stage dermal papilla cell-derived exosomes may enhance adipose stem cells' hair inductive abilities through specific miRNAs.
December 2021 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that BBS7 is crucial for maintaining Sonic hedgehog signaling activity and periodontal ligament homeostasis, with changes in gene expression observed in occlusal hypofunctional PDL.
20 citations
,
June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery” This review summarizes recent research and patents on 17β-HSD3, 17β-HSD5, and 3α-HSD3 inhibitors, suggesting their potential in treating androgen-dependent diseases, but reports no new clinical results.
1 citations
,
July 2022 in “Pakistan biomedical journal” This review discusses ethanol-based transethosome vesicles for drug delivery through the skin, but reports no new clinical results.
27 citations
,
July 2018 in “Experimental dermatology” This study found that autophagy plays a role in sebaceous gland function and sebum composition control in mice lacking the Atg7 gene in keratinocytes.