Androgen and Cortisol Secreting Adrenocortical Oncocytoma with Uncertain Malignant Potential

July 2019 in “ Journal of the ASEAN Federation of Endocrine Societies ”

Paulo Cassis C, S. L

androgen cortisol adrenocortical oncocytoma hyperandrogenism testosterone dehydroepiandrosterone sulfate adrenal tumor adrenalectomy Ki67 index hydrocortisone DHEA-S adrenal gland tumor cortisol treatment

TLDR The woman had a rare adrenal tumor removed, and she recovered well with no signs of the tumor returning.

The document reported a case of an 18-year-old woman with an androgen and cortisol-secreting adrenal oncocytic tumor of uncertain malignant potential. The patient presented with symptoms of hyperandrogenism, including irregular menstruation, amenorrhea, increased facial and limb hair, and voice deepening. Laboratory tests confirmed elevated testosterone and dehydroepiandrosterone sulfate levels, along with non-suppressed cortisol. Imaging revealed a large adrenal tumor, which was surgically removed. The tumor was identified as an oncocytic adrenal cortical neoplasm with low mitotic activity. Post-surgery, the patient was treated with hydrocortisone, which was tapered off, and follow-up scans showed no recurrence. The study concluded that due to the uncertain malignant potential of such tumors, close surveillance is necessary to monitor for recurrence.

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