Androgen and Cortisol Secreting Adrenocortical Oncocytoma with Uncertain Malignant Potential

An 18-year-old woman with a history of bronchial asthma presented with symptoms of hyperandrogenism, including irregular menstruation, amenorrhea, increased facial and limb hair, and voice deepening. She was diagnosed with an androgen and cortisol-secreting adrenal oncocytic tumor of uncertain malignant potential. Laboratory tests showed elevated testosterone and dehydroepiandrosterone sulfate levels, and a CT scan revealed a large adrenal tumor. She underwent successful adrenalectomy, and the tumor was identified as having low mitotic activity and a Ki67 index of less than 5%. Post-surgery, she was treated with hydrocortisone, which was tapered off, and follow-up scans showed no recurrence. The study highlighted the rarity of such tumors and the need for close surveillance due to their uncertain long-term behavior.