Aberrant Expression of Epidermal Growth Factor Receptor in Aural Cholesteatoma
March 1993
in “
The Laryngoscope
”
TLDR Cholesteatoma shows abnormal and increased EGF receptor expression, indicating its rapid growth.
The study investigated the expression of epidermal growth factor (EGF) receptors in normal human skin compared to aural cholesteatoma using a monoclonal antibody and the APAAP technique. It was found that EGF receptors were highly expressed in the basal layer of the epidermis, hair follicle apocrine sweat glands, and capillary system of normal skin. In contrast, cholesteatoma epithelium exhibited increased EGF receptor expression in the suprabasal layers, with heterogeneity observed in different parts of the cholesteatoma. These findings suggested aberrant regulation and persistence of EGF receptors in cholesteatoma, supporting its hyperproliferative nature.
