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The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Acne is a chronic disease linked to various systemic conditions and has significant psychological and social effects.

New treatments for hair loss are being developed using molecular biology.

Understanding how acne develops in different diseases could lead to new treatments.

Different levels of microRNAs in different parts of the scalp can cause male pattern baldness.

The same hormone can affect gene expression differently in various tissues, which could lead to new treatments for conditions like hair loss.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

ERG increases SOX9, promoting prostate cancer growth and invasion.

Early balding at 40 increases prostate cancer risk.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

AGEs may cause hair loss by increasing inflammation in hair follicles.

The document concludes that combination therapy is most effective for treating excessive hair growth in women with idiopathic hirsutism, and more research is needed to understand the condition.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Androgens like testosterone affect skin health and can lead to conditions such as acne and hair loss, with various treatments available.

Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

Androgens may block hair growth signals, targeting this could treat hair loss.

DHT stops hair regrowth in mice, similar to human hair loss.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Immune cells affect hair growth and could lead to new hair loss treatments.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

Dutasteride and finasteride affect different cell types differently.