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Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

Medications have become the main treatment for enlarged prostate symptoms, replacing surgery and watchful waiting.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Finasteride does not prevent bladder cancer.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Testosterone replacement therapy improves libido, mood, muscle strength, and bone density in men with Testosterone Deficiency Syndrome.

COVID-19 may worsen with androgens; anti-androgen drugs could help.

Men with male pattern baldness may be more at risk for severe COVID-19, and anti-androgen treatments could offer protection.

ERG increases SOX9, promoting prostate cancer growth and invasion.

Don't combine abiraterone and spironolactone for prostate cancer treatment as it may worsen the disease.

A new compound, 3a, effectively fights prostate cancer better than finasteride.

Androgens increase muscle mass by promoting myoblast growth through ornithine decarboxylase.

Finasteride helps treat prostate issues and may prevent prostate cancer in high-risk men.

5-Alpha reductase inhibitors may prevent prostate cancer but are not widely used due to concerns about trial relevance and potential risks, and more research is needed to confirm long-term benefits.

5α-reductase inhibitors don't stop bladder cancer from developing or getting worse.

Hormone replacement therapy may lower the risk of severe COVID-19 outcomes in non-immunosuppressed people and male organ transplant recipients.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

The same hormone can affect gene expression differently in various tissues, which could lead to new treatments for conditions like hair loss.

Testosterone helps human pancreatic cells increase insulin release.

Finasteride may cause kidney damage.

Hair loss may link to weaker COVID-19 immunity, suggesting possible need for extra vaccine boost.

Urologic diseases and treatments in older men can negatively affect fertility, and doctors should talk to patients about this.

The over-the-counter supplement DHEA could make COVID-19 worse, especially in diabetics and people with G6PD deficiency.

Using 5-alpha-reductase inhibitors may improve bladder cancer survival in men.

Androgens play a key role in hair growth and disorders like baldness and excessive hairiness.

A 13-year-old with 46 XY DSD had ambiguous genitalia due to incomplete masculinization.