Hormone Replacement Therapy and COVID-19 Outcomes in Solid Organ Transplant Recipients Compared With the General Population

    April 2023 in “ American Journal of Transplantation ”
    Amanda J. Vinson, Alfred Jerrod Anzalone, Makayla Schissel, Ran Dai, Evan French, Amy L. Olex, Roslyn B. Mannon, Adam B. Wilcox, Adam M. Lee, Alexis Graves, Alfred Jerrod Anzalone, Amin Manna, Amit Saha, Amy L. Olex, Andrea Zhou, Andrew E. Williams, Andrew M Southerland, Andrew T. Girvin, Anita Walden, Anjali Sharathkumar, Benjamin Amor, Benjamin Bates, Brian Hendricks, Brijesh Patel, G. Caleb Alexander, Carolyn Bramante, Cavin Ward‐Caviness, Charisse Madlock‐Brown, Christine Suver, Christopher G. Chute, Christopher Dillon, Chunlei Wu, Clare Schmitt, Cliff Takemoto, Dan Housman, Davera Gabriel, David Eichmann, Diego R. Mazzotti, Donald J. Brown, Eilis Boudreau, Elaine Hill, Elizabeth Zampino, Emily Carlson Marti, Emily Pfaff, Evan French, Farrukh M. Koraishy, Federico Mariona, Fred Prior, George Sokos, Greg S. Martin, Harold P. Lehmann, Heidi Spratt, Hemalkumar B. Mehta, Hongfang Liu, Hythem Sidky, J.W. Awori Hayanga, Jami Pincavitch, Jaylyn Clark, Jeremy Harper, Jessica Y. Islam, Jian Ge, Joel Gagnier, Joel Saltz, Joel Saltz, Johanna Loomba, John B. Buse, Jomol Mathew, Joni L. Rutter, Julie A. McMurry, Justin Guinney, Justin Starren, Karen Crowley, Katie R. Bradwell, Kellie M Walters, Ken Wilkins, Kenneth Gersing, Kenrick Cato, Kimberly Murray, Kristin Kostka, Lavance Northington, Lee Allan Pyles, Leonie Misquitta, Lesley Cottrell, Lili Portilla, Mariam Deacy, Mark M. Bissell, Marshall Clark, Mary Emmett, Mary Saltz, Matvey B. Palchuk, Melissa A. Haendel, Meredith E. Adams, Meredith Temple-O’Connor, Michael G. Kurilla, Michele Morris, Nabeel Qureshi, Nasia Safdar, Nicole Garbarini, Noha Sharafeldin, Ofer Sadan
    Image of study
    TLDR Hormone replacement therapy may lower the risk of severe COVID-19 outcomes in non-immunosuppressed people and male organ transplant recipients.
    The study involved 1135 solid organ transplant recipients (SOTRs) and 43,383 non-immunosuppressed/immunosuppressed (non-ISC) patients on hormone replacement therapy (HRT) with COVID-19. It found that HRT use was associated with a lower risk of major adverse renal or cardiac events and all secondary outcomes in non-ISC individuals. In SOTRs, HRT reduced the risk of acute kidney injury and mortality in males with COVID-19 but not in females. The study suggests that the benefits of HRT are likely mediated through an immune pathway that is inhibited in immunosuppressed transplant recipients. However, the potentially modifying effects of immunosuppression on the benefits of HRT require further investigation.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community 9 months on Finasteride 1,25mg + HRT

      in Transgender  16 upvotes 6 months ago
      The conversation is about the results of using hormone replacement therapy (HRT) with estrogen and finasteride for hair loss, and switching from finasteride to bicalutamide as an anti-androgen treatment. The user shared before and after photos to discuss the effectiveness of these treatments.

      community 2.5 years Minoxidil and HRT, CPA->Lupron +Minox 5%

      in Transgender  611 upvotes 1 week ago
      The user experienced significant hair regrowth after 2.5 years of using Minoxidil 5% and hormone replacement therapy (HRT) with Lupron, despite initial scalp irritation. Finasteride was ineffective for them.

      community 21 months on topical minoxidil and full HRT

      in Transgender  214 upvotes 6 months ago
      The conversation is about a transgender individual's experience with hair regrowth using topical minoxidil and hormone replacement therapy (HRT), expressing concern about the slow growth and thin appearance of their hair. Some responses encourage patience and highlight the variability of results, while others discuss the role of HRT and its effects.

      community 8 months on 5mg fin daily, 5% min twice daily, and hrt(mtf). Thought my hair was unrecoverable before but now I’m so happy.

      in Transgender  1904 upvotes 1 year ago
      A user named "LordGeek101" shared their positive experience with hair regrowth after using 5mg of finasteride daily, 5% minoxidil twice daily, and hormone replacement therapy (HRT) for 8 months. The user is transgender (MTF) and mentioned that the larger dose of finasteride was recommended by their doctor for better chances of hair revival.

      community Trans: Do I need to use Finnasteride?

      in Transgender 1 year ago
      A transgender individual is starting spironolactone and estradiol for hormone replacement therapy (HRT) and is considering adding finasteride to help with hair loss. They are also planning to use minoxidil and microneedle, but are unsure if they need to use another anti-androgen or more aggressive treatments. A respondent advises against using pyri and suggests waiting to see if the HRT alone is sufficient before becoming dependent on minoxidil.

    Similar Research

    5 / 1000+ results