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This study found that some synthesized heterocyclic derivatives showed promising 5α-reductase inhibitor, antiviral, and anti-tumor activities, surpassing several reference drugs in effectiveness.

In this review, the authors highlight the involvement of the 5α-reductase enzyme family in androgen-dependent disorders, noting the discovery of a novel isoform, SRD5A3, which is overexpressed in cancers with poor prognosis.

In this study, researchers identified several active metabolites in Eclipta alba, demonstrated strong interaction with Alzheimer's disease proteins, and found that 28 days of treatment improved memory without significant toxicity in rats, suggesting potential pathways for treating Alzheimer's.

This study reports the crystal structure of C28H32O5, revealing its monoclinic symmetry, unit-cell dimensions, and molecular conformation.

Researchers made two new compounds that could be used for medicine.

This study found that the presence of benzeneseleninic acid in commercial anhydride samples lowered the reaction rate during the oxidation of a finasteride intermediate compared to pure anhydride.

This study reports that citrulline, uniquely found in the inner root sheath of hair follicles, can be specifically detected with the carbamido diacetyl reaction, resulting in a bright orange color.

In this study, the synthesis of C-4 and C-6 bridged haptens of 11 alpha-hydroxyprogesterone revealed an unexpected formation of a C-4 substituted product using a 6-bromo derivative, contrary to prior reports.

This abstract details known indications, categories, and potential reactions for various drugs, including anorexiants, estrogens, NSAID analgesics, cardiac glycosides, and migraine preventives, without reporting new clinical results.

Glycoproteins are present in the cell membranes of various keratin fibers.

In this study, researchers developed and validated a method to quantify pyrrolizidine alkaloids in honey and flour, increasing alkaloid recovery rates through successive extractions, achieving up to 86% recovery for honey and 76% for flour.

This preliminary study of Alopecia Areata identified limited expression of certain metabolic transporters and enzymes in hair follicle immune cells, providing early insight into their unique energy needs.

This study found that adverse reactions to para-phenylenediamine in hair dye, including severe allergic contact dermatitis, may be more common than currently reported and often misdiagnosed.

This study found no correlation between clinical stages of androgenetic alopecia and serum DHEA-S levels in men, contrasting with previous studies suggesting elevated levels.

This research proposes to investigate the incidence of skin diseases in dogs from North-eastern India linked to deficiencies in alpha-linolenic and linoleic acids, as these essential fatty acids have anti-inflammatory and immunomodulatory benefits potentially aiding inflammatory skin disease therapy.

This review examines the patent literature on AKR1C3 inhibitors and suggests that although numerous potent inhibitors exist, further preclinical optimization is necessary before assessing their therapeutic potential in human diseases.

This study found that hydrophilic carbon dots (Lys-CA-CDs) induced bovine serum albumin to form more wormlike fibrils, while inhibiting hen egg white lysozyme from forming hair-like fibrils.

This study suggests that aroma oils categorized by scalp type have similar chemical compositions, potentially enhancing their effectiveness in aromatherapy for scalp issues.

This study suggests that the neurosteroid allopregnanolone contributes to stress resistance in mice, and the ALLO mimetic drug alfaxalone may offer anxiolytic benefits without muscle-relaxant effects.

This study proposes a new method to selectively isolate keratin-associated proteins and keratin from human hair, suggesting that KAPs may support keratin fibers in hair structure.

This study describes a microfluorometric method to quantify lipid removal and reattachment on human hair during light exposure and chemical treatments, altering hair surface properties from hydrophobic to hydrophilic.

This study found that waving virgin human hair with thioglycerol at pH 9.0 using ammonia solution caused less damage than using thioglycolic acid, while maintaining good waving efficiency.

This study concluded that bleach treatment partly transforms the hydrophobic top layer of human hair cuticles into a hydrophilic surface with clustered cysteic acid, visualized at the nano-scale using dynamic Chemical Force Microscopy.

This study found that a new deoxycholic acid derivative may offer a similar prostatoprotective effect to finasteride with lower toxicity in rat models.

This case study reported that two patients treated for androgenetic alopecia with Regaine® solution developed allergic contact dermatitis due to propylene glycol, highlighting the importance of testing the vehicle in patch tests.

This study observed that male human hair follicles metabolized dehydroepiandrosterone (DHA) more intensively than skin did and found altered DHA metabolism in follicles from balding individuals.

In this study, silver oxide-based nanoparticles were used to ionize analytes and detect specific target molecules through adduct formation with silver isotopes, facilitating signal correlation with these molecules.

This study optimized the reaction conditions for the stereoselective hydrogenation of a compound used in manufacturing finasteride and dutasteride, improving the selectivity for the desired isomer.

This study found that topical phenylephrine, an α1-AR agonist, significantly reduced hair shedding and increased epilation force threshold in women experiencing traction alopecia during cosmetic procedures.