Serum Concentrations of Dehydroepiandrosterone-Sulfate in Men with Androgenetic Alopecia

April 2012 in “ Journal of IMAB ”

Ani Tsvetanova, Dimitar Gospodinov

Dehydroepyandrosterone-sulfate DHEA-S androgenetic alopecia male pattern baldness DHT follicular enzymes AA

TLDR Men with male pattern baldness don't necessarily have high levels of Dehydroepyandrosterone-sulfate, and there's no link between its levels and the severity of hair loss.

The study from 11 years ago, "SERUM-CONCENTRATIONS OF Dehydroepyandrosterone-sulfate IN MEN WITH ANDROGENETIC ALOPECIA", aimed to determine the serum-levels of Dehydroepyandrosterone-sulfate (DHEA-S) in men with Androgenetic Alopecia (AA) and any possible correlation between the clinical stage of AA and DHEA-S levels. The study involved 44 men, 37 with male pattern baldness and 7 healthy controls, aged 19 to 55. The results showed that only nine of the men with AA had high levels of DHEA-S, and no correlation was found between the clinical stage of AA and DHEA-S levels. There was only a relationship between the increase of age and decrease of DHEA-S levels. Contrary to previous studies, no elevation of DHEA-S in men with AA was found, indirectly supporting the importance of some follicular enzymes that could increase the amount of alternative DHT-sources in AA.

View this study on journal-imab-bg.org →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research The Hair Follicle: A Paradoxical Androgen Target Organ

66 citations, January 2000 in “Hormone Research in Paediatrics”

Androgens can both promote and prevent hair growth due to differences in gene expression in hair follicles.

research The Molecular Basis of Androgen Insensitivity

25 citations, January 2000 in “Hormone Research in Paediatrics”

Mutations in the androgen receptor gene cause Androgen Insensitivity Syndrome, affecting sexual development.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations, September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Hormonal Parameters in Androgenetic Hair Loss in Males

21 citations, January 1991 in “Dermatology”

Men with male pattern hair loss have different levels of certain hormones compared to men without hair loss.

Similar Research

5 / 1000+ results

research Hormonal Profile in Indian Men with Premature Androgenetic Alopecia

25 citations, January 2013 in “International Journal of Trichology”

Premature balding in some men may be linked to altered hormones, but it's not the male equivalent to polycystic ovary syndrome or metabolic syndrome.

research Serum Concentrations of Dehydroepiandrosterone-Sulfate in Men with Androgenetic Alopecia

October 2004 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Men with hair loss don't necessarily have higher levels of the hormone DHEA-S, but this hormone tends to decrease with age.

research Antiandrogens and Androgen Inhibitors in Dermatologic Treatments

November 2020 in “Elsevier eBooks”

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

research Androgenetic Alopecia: A Review

153 citations, March 2017 in “Endocrine”

Male pattern baldness involves genetics, hormones, and needs better treatments.

research Androgenetic Alopecia in Adolescents: A Report of 43 Cases

35 citations, October 2006 in “Journal of Dermatology”

Teen hair loss common in boys, linked to family history and mild symptoms.