Serum Concentrations of Dehydroepiandrosterone-Sulfate in Men with Androgenetic Alopecia

April 2012 in “ Journal of IMAB ”

Ani Tsvetanova, Dimitar Gospodinov

Dehydroepyandrosterone-sulfate DHEA-S androgenetic alopecia male pattern baldness DHT follicular enzymes AA

Studysummary This study found no correlation between clinical stages of androgenetic alopecia and serum DHEA-S levels in men, contrasting with previous studies suggesting elevated levels.

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Research cited in this study

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research Hormonal Parameters in Androgenetic Hair Loss in Males

21 citations , October 2009 in “Dermatology”

This study found that male pattern hair loss may be associated with differences in serum levels of androstenedione, cortisol, 17 beta-estradiol, and luteinizing hormone, compared to controls.

research Hormonal Interaction And Hair Growth

15 citations , May 2002 in “PubMed”

This article explores the hormonal and genetic factors influencing androgenetic alopecia and identifies potential targets for treatment but reports no new clinical findings.

research Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla

61 citations , December 2001 in “Journal of Investigative Dermatology”

This study found that steroid sulfatase in the dermal papilla of hair follicles metabolizes dehydroepiandrosterone sulfate to support the development of androgenetic alopecia, suggesting potential for steroid sulfatase inhibitors as treatments.

research The Hair Follicle: A Paradoxical Androgen Target Organ

66 citations , January 2000 in “Hormone Research in Paediatrics”

This study suggests that the paradoxical effects of androgens on hair growth are due to differential gene expression in hair follicles, possibly established during embryogenesis.

research The Molecular Basis of Androgen Insensitivity

25 citations , January 2000 in “Hormone Research in Paediatrics”

This article reviews androgen insensitivity syndrome and highlights the factors contributing to phenotypic diversity in 46,XY patients with AR gene mutations, reporting no new clinical results.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Serum Elevation of Dehydroepiandrosterone Sulfate Associated with Male Pattern Baldness in Young Men

52 citations , March 1987 in “Journal of the American Academy of Dermatology”

This study found that men with rapidly progressive male pattern baldness had elevated serum dehydroepiandrosterone sulfate levels, suggesting that adrenal hyperactivity may contribute to alopecia in genetically susceptible young men.

research The Inheritance Of Common Baldness: To Be Or Not To Be?

203 citations , November 1984 in “Journal of the American Academy of Dermatology”

This study presents evidence suggesting that androgenetic alopecia is most likely inherited through a polygenic model, challenging the traditional view that it is caused by a simple Mendelian autosomal dominant gene.