Serum Concentrations of Dehydroepiandrosterone-Sulfate in Men With Androgenetic Alopecia

January 2004 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”

Ani Tsvetanova, Dimitar Gospodinov, Miroslav Donchev

Dehydroepiandrosterone-sulfate DHEA-S androgenetic alopecia male pattern baldness DHT endocrinology of hair follicle

TLDR Men with androgenetic alopecia do not have elevated DHEA-S levels.

The study aimed to determine the serum levels of Dehydroepiandrosterone-sulfate (DHEA-S) in men with androgenetic alopecia (AA) and explore any correlation with the clinical stage of AA. It involved 44 men, 37 with male pattern baldness and 7 healthy controls, aged 19 to 55. The results showed that only 9 men with AA had high levels of DHEA-S, and 3 had borderline high levels. No correlation was found between the clinical stage of AA and DHEA-S levels. However, an age-related decrease in DHEA-S concentrations was observed. Contrary to previous studies, this research did not find elevated DHEA-S levels in men with AA, supporting the role of follicular enzymes in alternative DHT sources and the "endocrinology of hair follicle" theory.

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