Extensive Challenges and Pending Advances in the Study of 5-Alpha-Reductase Isoenzymes: A Literature Review

August 2024 in “ Latin American Journal of Development ”

Iván Cortés-Pavía, Abel Moreno-Cárcamo, Abraham Landa-Piedra, Marisa Cabeza

5-alpha-reductase SRD5A androgenic alopecia SRD5A1 SRD5A2 SRD5A3 steroidal inhibitors non-steroidal inhibitors androgen-dependent disorders 5α-reductase androgenic hair loss

TLDR 5α-reductase enzymes are crucial in certain disorders, and while treatment advances exist, more research on SRD5A3 is needed.

This literature review examines the 5α-reductase enzyme family (SRD5A) and its involvement in androgen-dependent disorders, including androgenic alopecia. It highlights the discovery of a third isoform, SRD5A3, which is linked to poor prognosis in various cancers. The review notes the challenges in crystallizing these enzymes for structural analysis and mentions several effective inhibitors that have improved treatments for related conditions. While SRD5A1 and SRD5A2 are well-researched, the biochemical and physiological properties of SRD5A3 are not well understood, indicating a need for further study.

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