This study highlights the use of dermatoscopy as a valuable tool for diagnosing and monitoring alopecia areata, noting that specific hair shaft alterations such as exclamation-mark hairs and black dots are indicators of active disease, while vellus hairs signal early regrowth.
24 citations
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May 2006 in “Journal of Investigative Dermatology” This study found that allergen treatment in alopecia areata mice appeared to alter leukocyte subset distribution and impaired dendritic cell migration, which may affect T-cell activation and hair follicle recovery.
July 2020 in “Benha Journal of Applied Sciences” This study found that young male patients with grade III and IV androgenetic alopecia had elevated levels of serum amyloid A3, suggesting a higher risk of developing atherosclerosis compared to those without the condition.
January 2023 in “Pharmaceutics” In this study, researchers developed a new topical atraric acid formulation, AA-TF#15, which showed a significantly higher drug penetration and increased hair regrowth in mice compared to minoxidil and finasteride treatments, suggesting its potential effectiveness for treating scalp androgenic alopecia.
1 citations
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April 2016 in “Journal of The American Academy of Dermatology” Ixekizumab helps improve life quality, physical ability, and work performance in patients with psoriatic arthritis who haven't used biologic drugs before.
31 citations
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October 2010 in “Journal of the European Academy of Dermatology and Venereology” The authors concluded that some patients clinically diagnosed with telogen effluvium may actually have alopecia areata incognita, suggested by the presence of dystrophic hairs and development of alopecia patches.
December 2024 in “Indian Journal of Dermatology” This case report describes a 3-year-old boy with atrichia with papular lesions, emphasizing that dermoscopy, showing the 'cluster of stars' appearance, facilitated diagnosis without needing a skin biopsy.
1 citations
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July 2018 in “Elsevier eBooks” This research focuses on alopecia areata, highlighting the psychological impact, especially of its variant alopecia areata incognita, and provides diagnostic and treatment tips, but does not report specific results.
March 2026 in “Dermatology Online Journal” Medicaid coverage for alopecia areata treatments is inconsistent and often limited.
March 2022 in “Wound practice & research” This review synthesizes current evidence on alopecia areata, detailing its clinical features, pathogenesis, and treatment options, but does not present new clinical results.
January 2026 in “Frontiers in Molecular Biosciences” This study identified a four-gene loop as a non-invasive biomarker that selectively activates in alopecia areata, providing a precise target for JAK inhibitor treatments.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that OR-101, a selective JAK3/TEK inhibitor, was associated with dose-dependent improvements in hair growth in humanized mice with alopecia areata, suggesting its potential as a treatment option.
2 citations
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March 2025 in “Journal of Translational Autoimmunity” This study reports that AhR pathway expression is significantly reduced in lymphocytes of alopecia areata patients, suggesting its potential as a diagnostic marker and therapeutic target.
5 citations
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September 2011 in “Pediatric Dermatology” This case report describes androgenetic alopecia in two young siblings, highlighting its occurrence in children and suggesting a possible familial pattern given their mother's similar condition.
July 2024 in “Journal of Investigative Dermatology” JAK inhibitors improve hair growth in alopecia areata, especially in patchy types.
January 2026 in “Medicina” This review found that oral JAK inhibitors, used off-label in various inflammatory skin disorders, often resulted in rapid and sustained clinical improvements with acceptable safety over several months, although the evidence is drawn from case-based reports.
February 2025 in “PubMed” This case report observed successful hair regrowth with ritlecitinib in a patient with severe alopecia who did not respond to a previous year of baricitinib therapy.
19 citations
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October 2017 in “Dermatologic Surgery” In this study, 755-nm alexandrite laser treatment significantly reduced acne keloidalis nuchae lesions in male patients, improving quality of life and showing low recurrence rates, with temporary hair loss as a reversible complication.
April 2023 in “Journal of Dermatological Treatment” This study observed a significant reduction in the number of hair follicles with a high proportion in catagen or telogen phase, along with visible vertical columns of connective tissue in the histopathologic examination.
7 citations
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August 2024 in “Clinical and Experimental Dermatology” In this retrospective study conducted at a trichology clinic, the off-label use of upadacitinib for at least 24 weeks was found to have a promising efficacy and safety profile for treating severe alopecia areata in adolescents.
June 2026 in “Journal of Cosmetic and Regenerative Medicine” This study found that Janus kinase inhibitors significantly improve treatment outcomes for complex skin conditions like atopic dermatitis and alopecia areata, but their implementation requires careful safety considerations, including risk assessments for cardiovascular, malignant, and reproductive issues.
March 2022 in “Journal of Pakistan Association of Dermatologists” This article reviews the mode of action, efficacy, and safety of Janus kinase inhibitors in autoimmune dermatological conditions but reports no new clinical results.
November 2025 in “SKIN The Journal of Cutaneous Medicine” In this phase 3 trial, baricitinib showed effectiveness and safety in both adolescents and adults with severe alopecia areata, with adolescents achieving higher response rates despite more severe baseline conditions, suggesting the advantages of early treatment.
9 citations
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January 2015 in “Fundamental & clinical pharmacology” This study found that cyclosporine A's enhancement of hair growth in mice is partly due to its ability to block the nuclear translocation of apoptosis-inducing factor, slowing the hair follicle transition to the catagen phase.
1 citations
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August 2024 in “JAAD Case Reports” This report presents a rare case of diffuse hair loss resembling alopecia areata, following a tick bite on the scalp.
13 citations
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August 2018 in “Life sciences” This meta-analysis suggests that combining Kang-ai injection with platinum-based chemotherapy may improve tumor response, performance status, immune functions, and reduce adverse reactions in patients with advanced non-small cell lung cancer.
1 citations
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January 2017 in “Springer eBooks” This review discusses recent advances in understanding alopecia areata's disease mechanisms and highlights JAK molecules as promising therapeutic targets, but reports no new clinical results; controlled trials are needed.
2 citations
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March 2009 in “Journal of Clinical Dermatology” This study found that topical 5% minoxidil solution is effective and well tolerated for promoting hair growth in Korean men with androgenetic alopecia over 24 weeks.
March 2025 in “Journal of Investigative Dermatology” December 2025 in “Actas Dermo-Sifiliográficas” This review analyzes the mechanism and evidence supporting the approved use of ritlecitinib, a JAK3/TEC kinase inhibitor, for treating severe alopecia areata in patients aged 12 and older, highlighting its role in the changing therapeutic landscape of this immune-mediated disease.