Janus Kinase Inhibitors In Dermatology: An Update And Critical Review

    June 2026 in “ Journal of Cosmetic and Regenerative Medicine ”
    Kar Wai Alvin Lee, Kwin Wah Lisa Chan, Cheuk Hung Lee, Sky Wong
    Studysummary This study found that Janus kinase inhibitors significantly improve treatment outcomes for complex skin conditions like atopic dermatitis and alopecia areata, but their implementation requires careful safety considerations, including risk assessments for cardiovascular, malignant, and reproductive issues.
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    Research cited in this study 12

    1. Post-Marketing Safety Signals of Four JAK Inhibitors for Alopecia Areata: An Indication-Restricted FAERS Pharmacovigilance Study Journal of Dermatological Treatment · 2026
    2. Use Of Oral Janus Kinase Inhibitors For The Treatment Of Severe Alopecia Areata: Narrative Review And Real-World Experience Immunological Medicine · 2026
    3. Jak-Inhibitors Beyond The Label: Emerging Applications In Dermatology Medicina · 2026
    4. Janus Kinase Inhibitors for Alopecia Areata: A Review of Clinical Data Frontiers in Immunology · 2025
    5. A Review of Janus Kinase Inhibitor Use in Scarring Alopecia JAAD reviews. · 2025
    6. Comparative Efficacy of Oral Janus Kinase Inhibitors and Biologics in Adult Alopecia Areata: A Systematic Review and Bayesian Network Meta-Analysis Journal of the European Academy of Dermatology and Venereology · 2024
    7. The JAK/STAT Signaling Pathway: From Bench to Clinic Signal Transduction and Targeted Therapy · 2021
    8. A Comprehensive Literature Review of JAK Inhibitors in the Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021
    9. Emerging Topical and Systemic JAK Inhibitors in Dermatology Frontiers in Immunology · 2019
    10. Targeting the Janus Kinase Family in Autoimmune Skin Diseases Frontiers in Immunology · 2019
    11. JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2019
    12. Topical Janus Kinase Inhibitors: A Review of Applications in Dermatology Journal of the American Academy of Dermatology · 2018