3 citations
,
May 2021 in “Evidence-based Complementary and Alternative Medicine” This review discusses the potential antiaging effects of Chinese herbal medicines and suggests their role in regulating aging-related genes through various signaling pathways; it reports no new clinical results.
34 citations
,
April 2023 in “Climacteric” This review discusses the long-term effects of gender affirming hormone therapy and reports no new clinical findings, recommending a shared decision-making approach to balance benefits and risks for transgender individuals.
20 citations
,
May 2020 in “Experimental Dermatology” This review discusses age-related changes in scalp skin and their potential effects on hair follicle aging, but reports no new clinical results, calling for further investigation.
6 citations
,
May 2020 in “Nutrients” This review discusses the effects of calorie restriction on skin aging, highlighting its potential to benefit skin health by reducing age-related and photo-induced changes, although the impact of certain diets remains unexplored.
1 citations
,
January 1989 in “The Nishinihon Journal of Dermatology” In this study, minoxidil did not demonstrate any anti-aging effects on postconfluent hair follicle cells, as no difference was observed in cell proliferation or differentiation compared to controls.
19 citations
,
July 2015 in “Journal of Ginseng Research” In this study, Korean Red Ginseng showed protective effects against chemotherapy-induced premature hair follicle aging in an in vitro model by modulating specific cellular protein expressions.
1 citations
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January 2009 in “Drug delivery system” This article provides a detailed review of minoxidil's pharmacological effects for treating androgenic alopecia but reports no new clinical results.
April 2026 in “Preprints.org” The study found that enhancing quercetin bioavailability with EubioQuercetin may amplify its anti-aging effects in mice by modulating the gut microbiota and improving intestinal barrier function.
March 2025 in “Aging Cell” In this study on mice, elevated IGF-1 levels in the skin were linked to premature aging of hair follicles, but interventions like reducing IGF-1 or using senolytic treatments helped restore stem cell health and counteract aging effects.
187 citations
,
December 2005 in “Experimental Dermatology” This article discusses the role of estrogens in skin aging and reports no new findings; it highlights the potential of selective ER modulators to improve skin health without systemic side effects.
2 citations
,
January 2018 in “International Journal of Advanced Community Medicine” This study reported the formulation of a new cream combining niacinamide and retinol aimed at reducing hyperpigmentation and providing anti-aging and moisturizing effects. It found that the cream remained stable under various environmental conditions and did not cause skin irritation in patch tests.
33 citations
,
January 2022 in “Scientific Reports” This study found that loading CoQ10 into a protransfersomal emulgel improved its stability and anti-ageing effects in UV radiation skin-aged induced-mice, without causing skin irritation.
12 citations
,
November 2004 in “Photochemistry and Photobiology” In this study, a superoxide dismutase gel prevented hair graying in mice exposed to photosensitization, suggesting that antioxidants can protect against oxidative damage involved in hair aging.
5 citations
,
July 2025 in “Journal of Cosmetic Dermatology” This review highlights the benefits of using natural herbal extracts, containing compounds like polyphenols and flavonoids, in anti-aging skincare formulations, suggesting they offer moisturizing, antioxidant, and rejuvenating effects, especially when incorporated with nano-formulations for enhanced efficacy.
3 citations
,
July 2023 in “Plastic and reconstructive surgery/PSEF CD journals” This systematic review found that sole nanofat grafting in plastic and reconstructive surgery shows potential benefits for scar improvement and anti-aging, with increases in skin thickness, collagen, and elastic fibers, but the evidence level remains low and further research is needed.
April 2018 in “Journal of Investigative Dermatology” This study found that treating human dermal fibroblast cells with ginsenoside Rd increased the expression of mRNA associated with the dermal-epidermal junction, suggesting potential as an anti-aging cosmetic ingredient.
4 citations
,
December 2020 in “Scientific Reports” This study found that a mixture of plant extracts significantly improved skin barrier function, reduced inflammation, and exhibited anti-aging effects in human skin cells.
1 citations
,
February 2025 in “Journal of Biomedical Research & Environmental Sciences” This review explores the diverse health benefits and pharmacological properties of mushrooms, highlighting their potential use in cosmetics for antioxidant, anti-aging, and anti-hair loss effects due to their bioactive compounds.
January 2025 in “Journal of Controlled Release” This study developed a gas-propelled microneedle patch with puerarin/quercetin nanoparticles, which demonstrated improved hair-regenerating effects in an androgenetic alopecia mouse model by increasing drug delivery, alleviating oxidative stress, promoting angiogenesis, and rejuvenating senescent cells.
3 citations
,
June 2017 in “International Journal of Radiation Biology” This review of murine studies reports that γ-rays affect hair follicle pigmentation in mice throughout the hair cycle, while effects on hair structure may be obscured by aging.
6 citations
,
August 2024 in “PubMed” The authors report that topical skincare products containing Coenzyme Q10 can replenish CoQ10 levels, enhance skin's energy metabolism, and reduce the depth of wrinkles by providing antioxidant effects, which may help reverse signs of aging related to oxidative stress.
4 citations
,
October 2022 in “Frontiers in public health” In this study on C57BL/6 mice, researchers found that cadmium chloride exposure led to metabolic disruption, accelerated skin aging, and impaired hair regeneration, with more severe effects observed at higher doses.
November 2024 in “PubMed” This study found that carboxytherapy significantly improved skin wrinkles, laxity, and pigmentation among 28 patients with skin aging on the abdomen, accompanied by increased epidermis and dermis thickness and no significant side effects.
October 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers found that cochlear hair cell function declined with age in CBA/CaJ mice starting at 10 months, before detectable hearing loss, and was marked by a decrease in cell size and BK channel currents, without effect on MET currents.
126 citations
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January 2009 in “International Journal of Trichology” This review discusses the potential role of oxidative stress in hair graying and age-related alopecia, emphasizing the need for new strategies to counteract these effects, but reports no new results.
2 citations
,
May 2023 in “Marine Drugs” The researchers reported that marine-derived saccharides, specifically L-fucose and chondroitin sulphate disaccharide, supported skin and hair health by promoting cellular proliferation, enhancing extracellular matrix production, and aiding the hair cycle's growth phase, potentially minimizing aging effects.
December 2025 in “International Journal of Molecular Sciences” In this study, O. forskahlii seed oil was found to promote hair growth in rats and exhibit anti-aging effects on human skin cells by enhancing fibroblast proliferation and inhibiting inflammation and enzyme activity, indicating potential for cosmetic use.
October 2025 in “Journal of the Endocrine Society” This research review observed that topical hormone replacement therapy, particularly estradiol and estradiol-testosterone combinations, significantly increased Type I and III collagen synthesis in the skin of postmenopausal women, suggesting benefits against collagen loss-related skin aging effects such as reduced elasticity and increased dryness.
December 2022 in “Geriatrics” This study found that communication about aging across seven domains may predict successful aging in Indonesia through both positive and negative effects and efficacy toward aging.
62 citations
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July 2018 in “Lasers in Medical Science” In this review, the researchers highlight LED therapy as an emerging and safe treatment for skin inflammatory conditions, aging, and hair growth disorders, noting its integration into dermatological practice but emphasizing the need for more controlled studies to confirm its efficacy.