Hair Growth as Anti-Aging

January 2009 in “ Drug delivery system ”

Susumu Otomo

senile alopecia androgenetic alopecia male hormones hair cycle follicle miniaturization hair transplantation minoxidil finasteride ATP-sensitive K+ channels anti-androgen type II 5α-reductase Propecia Rogaine

TLDR Anti-aging treatments like hair transplants, minoxidil, and finasteride effectively promote hair growth.

The document discussed two types of hair loss associated with aging: senile alopecia and androgenetic alopecia. Senile alopecia resulted from follicle loss due to aging and did not follow a specific pattern, while androgenetic alopecia, influenced by male hormones, led to a characteristic pattern due to the shortening of the hair cycle's growth phase and follicle miniaturization. Androgenetic alopecia was of greater concern both aesthetically and psychologically. Anti-aging treatments included hair transplantation and medications, primarily minoxidil and finasteride. Minoxidil promoted hair growth by opening ATP-sensitive K+ channels, while finasteride acted as an anti-androgen by inhibiting type II 5α-reductase. Both treatments were clinically proven effective, with the document providing detailed pharmacological effects of minoxidil.

View this study on jstage.jst.go.jp →

Discuss this study in the Community →

Research cited in this study

15 / 15 results

research Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil

102 citations, February 2008 in “The FASEB Journal”

One minoxidil-sensitive potassium channel exists in human hair follicles.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations, July 2007 in “Journal of Investigative Dermatology”

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations, February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

research The Hair Growing Effect of Minoxidil

9 citations, December 2006 in “Annals of the New York Academy of Sciences”

Minoxidil helps hair growth by increasing blood flow and stimulating hair follicles.

research Different Gene Expression Profile Observed in Dermal Papilla Cells Related to Androgenic Alopecia by DNA Macroarray Analysis

47 citations, July 2004 in “Journal of Dermatological Science”

Hair loss in balding individuals is linked to changes in specific hair growth-related genes.

research Minoxidil Opens Mitochondrial KATP Channels and Confers Cardioprotection

28 citations, January 2004 in “British Journal of Pharmacology”

Minoxidil protects heart and improves recovery.

Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

research Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

190 citations, October 2002 in “The FASEB journal”

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

83 citations, December 2001 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations, February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations, January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

192 citations, March 1998 in “British Journal of Dermatology”

Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.

research Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp

227 citations, January 1998 in “Journal of Endocrinology”

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

research Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles

47 citations, May 1995 in “Journal of Investigative Dermatology”

Hair follicles in people with alopecia have lower levels of a key blood vessel growth protein.

research Quantitative Models for the Study of Hair Growth In Vivo

34 citations, December 1991 in “Annals of the New York Academy of Sciences”

The conclusion is that small hair follicles cause baldness in macaques, and treatments like antiandrogens and minoxidil can prevent hair loss and promote regrowth.

research The Stumptailed Macaque as a Model for Baldness: Effects of Minoxidil

18 citations, April 1986 in “International Journal of Cosmetic Science”

Minoxidil promotes hair regrowth in early baldness stages and prevents baldness in non-bald scalps.

Similar Research

5 / 352 results

research Female Pattern Hair Loss: A Clinical and Pathophysiological Review

91 citations, August 2015 in “Anais Brasileiros De Dermatologia”

Female Pattern Hair Loss affects women's self-esteem and needs more research for better treatment.

research Hair Loss in Elderly Women: A Dermatological Concern

30 citations, March 2010 in “European Journal of Dermatology”

Hair loss in elderly women is often caused by various factors, including hormonal changes after menopause.

research Aging and Anti-Aging in Hair and Hair Loss

1 citations, September 2013 in “Elsevier eBooks”

Hair ages and thins due to factors like inflammation and stress, and treatments like antioxidants and hormones might improve hair health.

research Hair Aging And Anti-Aging

3 citations, October 2007 in “Expert Review of Dermatology”

Hair ages due to various factors and treatments like minoxidil and finasteride can help, but more research and better public awareness are needed.

research Evaluation of Hair Loss

21 citations, May 1996 in “Current problems in dermatology”

Detailed patient history and physical exams are crucial for diagnosing hair loss.