The Effects of Minoxidil on Postconfluent Human Hair Follicle Cells

January 1989 in “ The Nishinihon Journal of Dermatology ”

Ryuichiro Kuwana, Seiji Arase, Yasushi Sadamoto, Kimitaka KANNO, Hideki Nakanishi, Katsuyuki Takeda

minoxidil hair follicle cells hair growth cell differentiation Rogaine

TLDR Minoxidil does not prevent aging in hair follicle cells.

The study investigated the effects of minoxidil on postconfluent human hair follicle cells to assess its hair growth-promoting properties. It was found that there was no significant difference in the number of cell passages or the number of viable cells between the minoxidil-treated group (10 μg/ml) and the control group. Additionally, there were no changes in the differentiation of hair follicle cells, as processes such as nuclear disappearance, cell enlargement, and cornified envelope formation were observed similarly in both groups. Therefore, minoxidil did not exhibit an anti-aging effect on hair follicle cells.

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Research cited in this study

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research Effect of Minoxidil on Cultured Human Hair Follicle Cells

3 citations , January 1988 in “The Nishinihon Journal of Dermatology”

Minoxidil slows hair cell growth but doesn't change cell shape or development.

Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

research Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

58 citations , June 1987 in “Archives of Dermatological Research”

EGF and FGF boost hair cell growth, hydrocortisone slows it, and minoxidil doesn't affect it.

research Effect of Minoxidil on Pre- and Postconfluent Keratinocytes

22 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil prolongs cell life, slows aging, and may produce longer hairs.

research Androgenetic Alopecia Treated With Topical Minoxidil

32 citations , March 1987 in “Journal of The American Academy of Dermatology”

Using minoxidil on balding men's scalps can increase hair growth, according to a 12-month study.

research Action of Topical Minoxidil in the Bald Stump-Tailed Macaque

78 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil promotes hair growth but stops working when discontinued.

research Effect of Minoxidil on Cultured Keratinocytes

72 citations , December 1983 in “Journal of Investigative Dermatology”

Minoxidil helps hair cells live longer and grow longer.

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Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

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The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

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Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

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