25 citations
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February 2022 in “JAAD International” This review analyzed data on alopecia types associated with COVID-19, suggesting androgenetic alopecia may be a risk factor for severe COVID-19, while telogen effluvium often follows infection and alopecia areata tends to relapse in those with preexisting disease.
4 citations
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August 2017 in “Journal of Cosmetic Dermatology” The study found that males with androgenetic alopecia had a significantly lower left-hand 2D:4D digit ratio compared to healthy controls, suggesting this ratio may help estimate future AGA risk.
December 2024 in “Medicine” This study suggests a potential genetic link between gut microbiota and androgenetic alopecia, identifying specific microbial taxa associated with either increased or reduced risk.
February 2018 in “PubMed” In a survey of dermatologists, 88% reported an increase in male androgenetic alopecia incidence among men under 30, suggesting possible social or environmental influences on genetic risk factors.
January 2021 in “Menoufia Medical Journal” This study found that patients with early-onset androgenetic alopecia had significantly higher levels of fasting blood sugar, triglycerides, and cholesterol, suggesting an increased risk of developing coronary artery disease.
47 citations
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June 2016 in “JAMA Dermatology” This study suggests men with early androgenetic alopecia might have hormonal profiles similar to women with polycystic ovarian syndrome, potentially indicating risk for related health complications.
4 citations
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January 2015 in “Indian Journal of Dermatology” This study reports that severe androgenic alopecia prevalence in young Caucasian men increases with age, varies by region, and that body mass index may be a risk factor.
1 citations
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October 2013 in “Our Dermatology Online” This study found that individuals in this Egyptian cohort carrying the leucine (L) allele of the 5-α reductase type II enzyme had a higher risk of developing androgenetic alopecia, which may be associated with oxidative stress.
March 2026 in “Jurnal Biomedika dan Kesehatan” In this pilot study of Indonesians, the rs1998076 genetic variant was not significantly linked to androgenetic alopecia, though the GG genotype showed a non-significant trend toward higher odds, while clinical factors like age and hypertension were correlated with increased risk.
May 2025 in “International Journal of Trichology” This study found that in males with androgenetic alopecia, greater severity was significantly associated with elevated total cholesterol and triglyceride levels, suggesting a need for cardiovascular risk screening.
This study found that among female patients, those who consumed sweetened tea drinks more frequently had a higher risk of androgenetic alopecia, with the impact notably mediated by late bedtimes rather than by sugar intake from these drinks.
October 2024 in “Molecular Nutrition & Food Research” This review found that deficiencies or imbalances in micronutrients like vitamin B, vitamin D, iron, and zinc may play a role in androgenetic alopecia and could be modifiable risk factors for prevention and treatment, though evidence varies.
December 2022 in “Sri Lanka Journal of Diabetes Endocrinology and Metabolism” This study found a significant association between early onset androgenetic alopecia and metabolic syndrome, with higher prevalence of metabolic risk factors in affected individuals compared to a control group.
September 2018 in “Fertility and Sterility” In this study, researchers observed that overweight Taiwanese women with PCOS who carry the HSD3B1 1245C allele have a significantly higher risk of developing androgenic alopecia compared to those with the wild-type allele.
31 citations
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February 2016 in “American Journal of Men's Health” This study found that nearly half of men using finasteride reported clinically significant depression, highlighting the need for psychiatric screening and careful risk assessment by prescribing clinicians.
24 citations
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January 2015 in “International Journal of Trichology” This research observed that among young men with androgenic alopecia, there was a significant association with metabolic syndrome compared to healthy controls, suggesting AGA as a potential early marker for metabolic risk.
13 citations
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June 2015 in “International Journal of Dermatology” In this study, non-obese females with early-onset androgenetic alopecia showed higher total cholesterol, LDL cholesterol, triglycerides, and atherogenic index, and lower HDL cholesterol compared to controls, suggesting an association with adverse cardiovascular risk factors.
5 citations
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July 2016 in “Journal of Clinical Hypertension” This study found that hypertensive patients with severe androgenic alopecia exhibited impaired coronary microcirculation, suggesting they may face increased cardiovascular risk.
4 citations
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January 2016 in “Annals of Dermatology” This study found that men with more advanced androgenetic alopecia had increased epicardial fat thickness, suggesting a potential link to coronary risk.
3 citations
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November 2020 in “Journal of The American Academy of Dermatology” This paper discusses the proposal that androgenetic alopecia, as seen in the "Gabrin sign", could indicate higher risk of severe COVID-19 symptoms, but its validity is questioned and further confirmation is needed.
2 citations
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September 2023 in “Health science reports” This meta-analysis found a strong association between metabolic syndrome and certain skin diseases, including psoriasis, hidradenitis suppurativa, androgenetic alopecia, and lichen planus, suggesting increased risk compared to the general population.
2 citations
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January 2022 in “Skin appendage disorders” This study found that for people with androgenetic alopecia, increasing the dosage of low-dose oral minoxidil is associated with improvements in hair diameter and density, but also raises the risk of hypertrichosis and cardiovascular adverse events.
1 citations
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January 2017 in “International Journal of Research in Medical Sciences” This study found that metabolic syndrome was 4.6 times more common in patients with androgenetic alopecia than in controls, particularly among those with severe grades, suggesting a higher risk of cardiovascular diseases.
1 citations
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August 2015 in “Current Sexual Health Reports” This review examines the sexual side effects of 5α-reductase inhibitors like finasteride, highlighting the increased risk of erectile dysfunction, libido reduction, and potential contribution to depression without new clinical findings.
1 citations
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August 2009 in “ACTUALIDAD MEDICA” In this study, early-onset androgenetic alopecia patients showed a higher prevalence of metabolic syndrome and carotid atheromatosis compared to a control group, suggesting the need for cardiovascular risk screening in this population.
In this study, researchers optimized the soft drug AR antagonist 14-P1 to create candidate 39, which demonstrated effective AR antagonism and safety in a hair-growth mouse model, showing similar efficacy to pyrilutamide but with quicker onset and a lower risk of systemic toxicity.
In a mouse hair-growth model, this study found that the optimized compound 39 matched the efficacy of pyrilutamide for androgenic alopecia, with faster response and maintained safety, suggesting it as a promising topical AR antagonist with reduced systemic toxicity risk.
March 2026 in “Dermatology Online Journal” In this study, androgenetic alopecia was linked to a higher likelihood of hyperlipidemia in both men and women and obesity in women, highlighting it as a potential marker for cardiometabolic risk.
December 2025 in “Revista fisio&terapia.” This study found that androgenetic alopecia treatments, especially dutasteride, are associated with a small increased risk of adverse events like sexual dysfunction and dermatologic reactions.
November 2025 in “Y HOC TP HO CHI MINH” This study from Ho Chi Minh City Dermatology Hospital reported that patients with androgenetic alopecia had a significantly higher prevalence of metabolic syndrome (38.7%) compared to the general population (12.9%), with a longer duration or severity of hair loss increasing their risk.