44 citations
,
April 2008 in “The Journal of Clinical Endocrinology & Metabolism” This study concluded that although RBP4 and adiponectin levels are associated with visceral fat, they do not independently contribute to the development of PCOS.
1 citations
,
November 2023 in “Anais Brasileiros de Dermatologia” This study suggests that the ADIPOQ gene polymorphism may influence the risk of alopecia areata in Egyptians, with adiponectin levels potentially serving as a marker for hair loss severity.
2 citations
,
October 2024 in “Endocrine Connections” This study found that serum APN levels were inversely related to insulin resistance in women with PCOS, suggesting that APN could serve as a clinical marker for insulin resistance in this population.
April 2024 in “Zagazig University Medical Journal” This study found a strong negative correlation between serum adiponectin levels and severity of hair loss in individuals with alopecia areata, suggesting adiponectin as a potential marker for disease severity.
17 citations
,
January 2016 in “Advances in Dermatology and Allergology” In this study, isotretinoin treatment for acne vulgaris significantly increased serum adiponectin and leptin levels but had no significant effect on BMI or ghrelin levels.
5 citations
,
July 2010 in “Archives of Internal Medicine” This study observed that topical prostaglandin treatments may protect against hair follicle injury during chemotherapy, as indicated by preserved eyelashes in patients using these treatments.
21 citations
,
September 2019 in “Archives of Physiology and Biochemistry” In this study, HIIT increased adiponectin levels and improved cholesterol profiles in women with PCOS, but did not change leptin or vaspin levels.
3 citations
,
April 2019 in “Hormone and Metabolic Research” This study found that women with polycystic ovary syndrome have higher insulin resistance and lower serum high-molecular weight adiponectin, which may play a role in the condition's pathogenesis.
This study found a weak and negative correlation between depression and adiponectin levels in women with polycystic ovary syndrome, which was statistically significant.
March 2013 in “Journal of pediatric nursing” This case report presents a 14-year-old girl with type A insulin resistance, illustrating diagnostic processes to differentiate it from type 2 diabetes in the context of pediatric obesity and hyperglycemia.
January 2026 in “Egyptian Journal of Dermatology and Venerology” This study found that androgenetic alopecia is associated with insulin resistance, elevated adipokines levels, and dyslipidemia in males, while female patients generally maintained a normal hormonal profile.
155 citations
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March 2006 in “The American Journal of Medicine” This study found that young women with polycystic ovary syndrome have altered endothelial function associated with insulin resistance and lower adiponectin levels.
3 citations
,
May 2023 in “Biomedicines” This article reviews the immunometabolic mechanisms linking polycystic ovary syndrome to infertility and stresses the need for interdisciplinary approaches to treat PCOS-related fertility issues; it reports no new clinical results.
October 2025 in “The Egyptian Journal of Hospital Medicine” This study found that patients with alopecia areata had lower adiponectin levels and higher leptin levels compared to healthy controls, with leptin levels correlating positively with insulin resistance markers and negatively with HDL cholesterol.
November 2023 in “British journal of nutrition” This study found that curcumin supplementation in adults significantly increased serum adiponectin levels and decreased leptin levels, based on a meta-analysis of 13 randomized controlled trials.
November 2007 in “Cancer Epidemiology and Prevention Biomarkers” In this study, PSA levels were significantly lower among African-American men with higher C-peptide levels and Caucasian men with higher HbA1c levels, suggesting a link between metabolic markers and prostate cancer detection.
26 citations
,
June 2014 in “Fertility and Sterility” In this study, normal weight adolescents with PCOS showed increased insulin resistance and significantly lower levels of high molecular weight adiponectin compared to controls, despite no other metabolic differences.
February 2023 in “Clinical, Cosmetic and Investigational Dermatology” This study found that male patients with Androgenetic alopecia have higher serum leptin, lower vitamin D levels, and an altered adiponectin/leptin ratio, which may contribute to the disease's pathogenesis.
24 citations
,
April 2008 in “Fertility and sterility” In this study, pioglitazone treatment in insulin-resistant PCOS patients decreased relative 5alpha-reductase activity without significantly affecting cortisol levels or urinary cortisol excretion.
19 citations
,
March 2007 in “Journal of diabetes science and technology” This study found that both metformin and rosiglitazone improved ovulation and insulin sensitivity in women with PCOS, with rosiglitazone showing a more pronounced increase in adiponectin levels.
November 2025 in “Journal of Kufa for Chemical Sciences” This study suggests that L-Selectin and adiponectin may be useful markers for distinguishing between Metformin-treated and untreated PCOS patients.
1 citations
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October 1996 in “Dermatologic clinics” This study found that higher levels of adiponectin were associated with reduced inflammation and osteolysis, suggesting potential therapeutic benefits for patients with aseptic loosening of joint replacements.
October 2017 in “The Egyptian Journal of Hospital Medicine ” This review discusses the clinical features, risk factors, and management options for polycystic ovary syndrome, but reports no new clinical findings; it underscores the importance of appropriate diagnosis and management to prevent complications.
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that the outer root sheath of human hair follicles may act as a "metabolic center," capable of synthesizing glucose from lactate, which supports glycogen metabolism.
218 citations
,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that removing PPARγ specifically from mouse adipose tissue led to severe fat loss, insulin resistance, diabetes, and associated metabolic abnormalities.
129 citations
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January 2019 in “Clinical medicine insights” This review discusses the mechanisms linking obesity and polycystic ovary syndrome and explores potential management options, but it presents no original research findings.
March 2023 in “Здобутки клінічної і експериментальної медицини” This study found that in adolescents with excess weight and obesity, vitamin D levels are inversely correlated with leptin and positively correlated with adiponectin, influencing metabolic exchange criteria.
July 2020 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that adding pioglitazone to either spironolactone or metformin improved metabolic parameters and insulin resistance in women with PCOS, despite an increase in BMI.
February 2020 in “İstanbul medical journal” This study evaluated the effects of metformin, ethinyl estradiol/cyproterone acetate (EE/SA), and their combination on carotid intima-media thickness and various cardiovascular markers in patients with polycystic ovary syndrome.
28 citations
,
November 2007 in “Medical Clinics of North America” This review discusses the impact, pathophysiology, and health risks of obesity and the metabolic syndrome in polycystic ovarian syndrome, emphasizing the potential life-saving benefits of recognition and treatment, but it reports no new results.