The Effects of Metformin, Ethinyl Estradiol/Cyproterone Acetate, and Their Combination Therapy on Carotid Artery Intima-Media Thickness in Patients with Polycystic Ovary Syndrome

February 2020 in “ İstanbul medical journal ”

Derya Ünal, Hüseyin Demirci, Murat Yılmaz, Üçler Kısa, Murat Tulmaç, Sefa Güliter

metformin ethinyl estradiol cyproterone acetate combination therapy polycystic ovary syndrome PCOS adiponectin apelin CRP HOMA-IR carotid artery intima-media thickness IMT subclinical atherosclerosis EE/CA

TLDR Metformin improves early signs of heart disease in women with PCOS and raises apelin levels, but doesn't significantly change artery thickness.

The study, involving 60 women with polycystic ovary syndrome (PCOS) and 43 healthy controls, examined the impact of metformin, ethinyl estradiol/cyproterone acetate (EE/CA), and their combination on carotid artery intima-media thickness (IMT) and cardiovascular risk markers. After six months, PCOS patients showed higher CRP, HOMA-IR, and IMT levels, and lower adiponectin and apelin levels than controls. Treatment with metformin and the combination therapy significantly increased adiponectin and apelin levels, but did not significantly change CRP levels or carotid IMT. The study concluded that metformin positively affects subclinical atherosclerosis in PCOS patients, despite no significant decrease in carotid IMT, and highlighted the novel finding of increased serum apelin levels across all treatment groups.

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Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome

research Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome

200 citations, October 2009 in “European journal of endocrinology”

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.