The Effects of Metformin, Ethinyl Estradiol/Cyproterone Acetate, and Their Combination Therapy on Carotid Artery Intima-Media Thickness in Patients with Polycystic Ovary Syndrome

February 2020 in “ İstanbul medical journal ”

Derya Ünal, Hüseyin Demirci, Murat Yılmaz, Üçler Kısa, Murat Tulmaç, Sefa Güliter

metformin ethinyl estradiol cyproterone acetate combination therapy polycystic ovary syndrome PCOS adiponectin apelin CRP HOMA-IR carotid artery intima-media thickness IMT subclinical atherosclerosis EE/CA

TLDR Metformin improves early signs of heart disease in women with PCOS and raises apelin levels, but doesn't significantly change artery thickness.

The study, involving 60 women with polycystic ovary syndrome (PCOS) and 43 healthy controls, examined the impact of metformin, ethinyl estradiol/cyproterone acetate (EE/CA), and their combination on carotid artery intima-media thickness (IMT) and cardiovascular risk markers. After six months, PCOS patients showed higher CRP, HOMA-IR, and IMT levels, and lower adiponectin and apelin levels than controls. Treatment with metformin and the combination therapy significantly increased adiponectin and apelin levels, but did not significantly change CRP levels or carotid IMT. The study concluded that metformin positively affects subclinical atherosclerosis in PCOS patients, despite no significant decrease in carotid IMT, and highlighted the novel finding of increased serum apelin levels across all treatment groups.

View this study on cms.galenos.com.tr →

Discuss this study in the Community →

Related Community Posts Join

6 / 31 results

community Topical rapamycin, metformin, a-kg grow hair

in Research/Science 13 upvotes 4 years ago

The conversation discusses the potential of topical rapamycin, metformin, and alpha-ketoglutarate (a-KG) for hair growth, with skepticism expressed about their effectiveness based on personal experience and existing use. It also mentions AICAR, known as cardarine or GW, which is not suitable for long-term use due to cancer risks in animal studies and its similarity to metformin.

community Finasteride and Metformin together?

in Finasteride/Dutasteride 1 upvotes 1 year ago

The conversation is about whether it's safe to take Metformin for weight loss and Finasteride together, with the concern that Finasteride is not commonly used for hair loss treatment in the user's location, and their doctor is not knowledgeable about it.

community Research suggests that drugs rapamycin and metformin have hair regeneration properties

3 upvotes 6 years ago

Rapamycin and metformin may have hair regeneration properties. Specific treatments discussed include Minoxidil, finasteride, and RU58841.

community What can I use to prepare a lotion that doesn't irritate my scalp or make my hair sticky? (Want to experiment with metformin and Alpha Keto glutarate)

in Product 2 upvotes 1 year ago

The conversation is about a user who tried dissolving a metformin pill in water for hair treatment but faced issues with hair sticking together. The user is seeking advice on preparing a non-irritating, non-sticky lotion at home, possibly experimenting with metformin and Alpha Keto glutarate.

community Anti-Androgens causing hairline to recede?

in Research/Science 5 upvotes 4 months ago

Anti-androgens like Finasteride, Dutasteride, Metformin, and Topical Spironolactone cause hairline recession and increased cholesterol levels. The hairline recovers after stopping the drugs.

community Akkermansia improves testosterone-induced hair growth inhibition.

in Research/Science 3 upvotes 11 months ago

Akkermansia bacteria can improve hair growth inhibited by testosterone, and metformin may increase Akkermansia, which could help with hair loss related to aging, insulin resistance, and inflammation.

Related Research

1 / 1 results

Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome

research Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome

200 citations, October 2009 in “European journal of endocrinology”

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.