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The document concludes that doctors should thoroughly check postmenopausal women with sudden increased male traits for rare conditions like androgen-producing endometrial cancer.

A woman's ovarian fibroma caused high testosterone levels, which normalized after surgery.

A 21-year-old male with a rare genetic disorder experienced sudden hair loss and high DHEAS levels, likely due to a condition similar to PCOS, usually seen in women.

Congenital Adrenal Hyperplasia is a rare inherited disease causing hormone imbalances, affecting growth, fertility, and heart health, diagnosed through blood tests and treated with medication and lifestyle changes.

Long-term opioid use can cause a serious condition where the adrenal glands don't work properly, which doctors should watch out for.

A 13-year-old boy with Cushing syndrome has high cortisol levels from a pituitary gland issue and underdeveloped sexual characteristics.

Taking thyroid medication reduced the patient's pituitary gland swelling and improved her symptoms.

A rare ovarian tumor that produced testosterone caused a blood clot in the lungs and increased red blood cells in a woman.

An ovarian tumor caused a woman's male-like symptoms, which improved after surgery.

A rare adrenal tumor in a woman only made DHEA-S, causing hair thinning, and was removed, fixing the hormone level.

A young patient with unusual insulin resistance and high testosterone levels had a rare INSR gene mutation.

The removal of the adrenal tumor improved the patient's symptoms and reduced androgen levels, indicating successful surgery.

A new mutation in the CYP11B1 gene was found in a woman with mild hyperandrogenemia, a rare cause of non-classic congenital adrenal hyperplasia.

Removing a hormone-producing adrenal tumor can stop hair loss in women with high testosterone levels.

Budesonide is not effective for maintaining remission in Crohn's disease beyond three months.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.

Scalp cooling effectively reduces hair loss from chemotherapy.

New hair growth corticosterone levels are higher in diabetic mice, indicating long-term stress.

P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.

TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.

Combining amino acid and stem cell therapy may help manage hepatocutaneous syndrome in dogs.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Silencing certain circadian clock genes increases skin pigmentation.

Certain daily habits like stress, diet, and sleep can affect the severity of hair loss in alopecia areata.

The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).

Hair is important for protection, social interaction, and temperature control, and is made of a growth cycle-influenced follicle and a complex shaft.

Male C57BL/6 mice show age-related fluctuations in certain hormones and their ratios in both blood and hair.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Laser hair removal is effective for hirsutism when combined with treatment for the underlying causes.