Age-Related Changes in Endogenous Glucocorticoids, Gonadal Steroids, Endocannabinoids, and Their Ratios in Plasma and Hair from Male C57BL/6 Mice
January 2021
in “
General and comparative endocrinology
”
glucocorticoids gonadal steroids endocannabinoids plasma hair biomarker HPA axis HPG axis ECS endocrine system stress hormones sex hormones cannabinoid system blood hair sample biological marker hypothalamic-pituitary-adrenal axis hypothalamic-pituitary-gonadal axis endocannabinoid system hormone system
TLDR Male C57BL/6 mice show age-related fluctuations in certain hormones and their ratios in both blood and hair.
The study examined age-related changes in glucocorticoids, gonadal steroids, endocannabinoids, and their ratios in plasma and hair of male C57BL/6 mice from 21 days to 10 months old. It found that concentrations of these compounds varied with age, with hair samples showing less variability than plasma, suggesting hair as a more stable biomarker. The ratios between these compounds could serve as reliable indicators of interactions within and between the HPA, HPG axes, and ECS, providing insights into the endocrine system's age-dependent activities and interactions.
