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GlossaryHypothalamic-Pituitary-Gonadal Axis (HPG Axis)

regulates reproductive hormones through interactions between brain and gonads

The Hypothalamic-Pituitary-Gonadal (HPG) Axis is a complex set of interactions among the hypothalamus, pituitary gland, and gonads (ovaries in females and testes in males) that regulate reproductive function and hormone production. This system controls the release of hormones like GnRH (gonadotropin-releasing hormone), LH (luteinizing hormone), and FSH (follicle-stimulating hormone), which are crucial for processes such as puberty, menstrual cycles, and sperm production.

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research Sex Differences in the Hypothalamic–Pituitary–Adrenal Axis’ Response to Stress: An Important Role for Gonadal Hormones

197 citations, January 2019 in “Neuropsychopharmacology”

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

research Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male

70 citations, March 2016 in “Urologic Clinics of North America”

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

research Beyond Testosterone Cypionate: Evidence Behind the Use of Nandrolone in Male Health and Wellness

11 citations, March 2016 in “Translational Andrology and Urology”

Nandrolone might increase muscle mass with fewer side effects than testosterone but could cause erectile dysfunction and needs more research.

research Microglia: Sculptors of the Polycystic Ovary Syndrome-Like Brain?

1 citations, June 2023 in “Reproduction”

Microglia, the brain's immune cells, may contribute to Polycystic Ovary Syndrome (PCOS) by altering the female brain's structure and function, with kisspeptin neurons and GABA neurotransmitters also playing a role.

research The Genetics of Autism and Steroid-Related Traits in Prenatal and Postnatal Life

1 citations, May 2023 in “Frontiers in Endocrinology”

Autism's genetics are linked with early age of puberty and less hair loss, but not with hormone levels or polycystic ovary syndrome.

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community Pyrilutamide: Increased libido. Anyone else experienced something similar with either RU or Pyri?

in Product 17 upvotes 2 years ago

An increase in libido associated with the use of Pyri, and a discussion about how it may be working comparably to other hair loss treatments such as RU58841, Finasteride and Minoxidil.

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 1 year ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

community Possible "Cure" For Pos Finasteride Syndrome

in Chat 6 upvotes 4 years ago

A user reported full recovery from Post Finasteride Syndrome after 6 months of HCG treatment. They used 250IU of HCG three times a week.

community Embraced baldness. Time to leave this subreddit

in Chat 876 upvotes 4 months ago

A user shared their positive experience of embracing baldness after years of trying treatments like Minoxidil and finasteride. They found happiness and confidence by shaving their head, despite some social challenges, and encouraged others to focus on their attitude and seek therapy if needed.

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 88 upvotes 4 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.