LC-APCI+-MS/MS Method for the Analysis of Ten Hormones and Two Endocannabinoids in Plasma and Hair from Mice with Different Gut Microbiota

    February 2020 in “ Journal of pharmaceutical and biomedical analysis ”
    Liuxi Chu, Na Li, Jia Deng, Yan Wu, H. Yang, Wei Wang, Dongrui Zhou, Huihua Deng
    TLDR The method accurately measures hormones and endocannabinoids in mice, showing gut microbiota diversity affects these levels and may influence stress and reproductive systems.
    The study developed a sensitive LC-APCI+-MS/MS method to simultaneously determine 12 compounds, including hormones and endocannabinoids, in mice's plasma and hair. The method was validated and reliable, showing sex differences in testosterone levels. Mice with different gut microbiota exhibited significant differences in hair levels of corticosterone, 11-dehydrocorticosterone, and aldosterone, indicating that gut microbiota can influence long-term neuroendocrine activity.
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