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research Patient-reported outcomes, provider-reported outcomes, and physiologic parameters after gender-affirming hormone treatment in Canada: a systematic review

January 2025 in “HORMONES”

This systematic review reported positive outcomes with gender-affirming hormone therapy in Canada and emphasized the urgent need for standardized outcome measurement tools to enhance evidence-based practices.

research 53039 The prevalence of androgenetic alopecia with hormone therapy in transgender men: a systematic review and single-arm meta-analysis

September 2024 in “Journal of the American Academy of Dermatology”

This study aims to evaluate the prevalence of androgenetic alopecia in transgender men undergoing testosterone therapy, noting that such hormone treatment can lead to dermatological issues that significantly affect their quality of life. Results are not reported in the abstract.

research Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis

91 citations , December 2017 in “Systems Biology in Reproductive Medicine”

This meta-analysis found that lower serum SHBG levels are associated with an increased risk of PCOS, and improving SHBG levels through treatment may reduce PCOS complications.

research Beyond Hormones: A Systematic Review of the Risk of Cardiovascular Diseases in Polycystic Ovary Syndrome

10 citations , November 2024 in “Cureus”

This systematic review identified several factors contributing to increased cardiovascular risk in women with polycystic ovary syndrome, including insulin resistance, obesity, inflammation markers, and microbiota alterations linked to elevated trimethylamine-N-oxide levels.

research A Systematic Review of the Effects of Exercise on Hormones in Women with Polycystic Ovary Syndrome

98 citations , May 2020 in “Journal of Functional Morphology and Kinesiology”

This review finds that vigorous aerobic exercise and resistance training may improve insulin sensitivity and androgen levels in women with PCOS, though more research is needed for definitive conclusions.

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Community Join

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community Why are hormone blockers more socially acceptable than hair systems or balding?

in Chat 105 upvotes 6 months ago

Finasteride is more accepted than hair systems because it is less visible and maintains natural hair. Treatments like minoxidil and finasteride are commonly used for hair loss, but opinions on hair systems vary.

community Anyone tried winlevi for hair loss? I am curious about it as someone who doesn’t want to change my hormones systemically.

2 upvotes 5 months ago

Winlevi is being considered for hair loss by someone who wants to avoid systemic hormonal changes. Minoxidil, finasteride, and RU58841 are also mentioned as treatments.

community Any treatment not nuking systemic DHT levels?

16 upvotes 7 months ago

Hair loss treatments that avoid significantly lowering systemic DHT levels, focusing on topical options like dutasteride mesotherapy, minoxidil, and ketoconazole. The user is exploring alternatives like KX-826 and RU58841 due to concerns about hormone levels.

community Dutasteride mesotherapy doesn’t impact your bodies serum hormone levels?

2 upvotes 1 year ago

Dutasteride mesotherapy may stabilize hair loss and improve hair without significantly affecting serum DHT levels, but it can still have systemic effects. Users discuss using topical and oral dutasteride, with some experiencing side effects and considering hair transplants.

community Estradiol mesotherapy / idea feedback

5 upvotes 1 year ago

The conversation discusses using estradiol mesotherapy to replicate hormone replacement therapy results while minimizing systemic exposure. It also covers the use of Spironolactone cream, which reportedly has no systemic side effects, and the potential risks of using bicalutamide and Spironolactone in men.

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Learn

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learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

learn Estradiol

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.
Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol helps treat hair loss by balancing hormones and supporting hair follicle health.

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Fluridil

a topical anti-androgen with less systemic involvement

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

learn sh-Polypeptide-7

learn Centella

Sensitive to hormones? A centella scalp mask may help ease hidden inflamm Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

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