Hormone-Related Hair Disorders: From Clinical Needs to New Therapeutic Perspectives

    August 2006 in “ Experimental dermatology
    Ulrike Blume‐Peytavi, Nathalie Mandt, J. Lademann, Annika Vogt
    TLDR New treatments targeting insulin, blood flow, and inflammation could improve hormone-related hair conditions with fewer side effects.
    The document discussed the role of hormones in hair follicle function and related disorders such as hair loss, seborrhoea, and hirsutism. Traditional treatments included systemic androgen inhibitors and topical estrogens. Emerging therapies focused on insulin sensitivity (rosiglitazone, metformin), blood flow regulation (minoxidil), and anti-inflammatory compounds. Future research aimed to identify new targets beyond sex steroids, such as components of the POMC-system, and to develop advanced drug delivery systems like microparticles for targeted treatment, potentially reducing side effects and increasing efficacy. The study highlighted the importance of individualized treatment strategies for hormone-related hair disorders.
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