A Case of Pituitary Hyperplasia Secondary to Uncontrolled Primary Hypothyroidism

    April 2020 in “ Journal of the Endocrine Society ”
    Hebah Alhumaidi, Sudha Rao, Dhruv Kansal
    TLDR Taking thyroid medication reduced the patient's pituitary gland swelling and improved her symptoms.
    A 17-year-old female with a history of papillary thyroid cancer and non-compliance with Synthroid developed galactorrhea, significant weight gain, headaches, fatigue, and other symptoms. Initial tests showed elevated prolactin (143.7 ng/mL) and TSH (996 mIU/L), and an MRI revealed a pituitary macroadenoma. After resuming Synthroid, her TSH and prolactin levels improved, and a follow-up MRI showed reduced pituitary hyperplasia. Her symptoms, including galactorrhea and headaches, resolved, and her fatigue significantly improved.
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