5 citations
,
December 2015 in “Dermatologic Therapy” In this study, topical phenylephrine significantly reduced hair shedding and increased the force needed to pluck hair in women undergoing cosmetic procedures, suggesting its potential utility for traction alopecia.
26 citations
,
October 1997 in “Planta Medica” This study found that bisbenzylisoquinoline alkaloids from Stephania cepharantha Hayata stimulated growth in cultured murine hair cells but not in keratinocytes or fibroblasts.
15 citations
,
July 2002 in “Australasian Journal of Dermatology” In this case report, two plywood mill workers developed allergic contact dermatitis due to exposure to uncured phenol-formaldehyde resin, not sawdust as initially suspected.
October 2025 in “Journal of Ethnopharmacology” Andrographolide from Andrographis paniculata promotes hair growth and could be a natural treatment for hair loss.
3 citations
,
June 2023 in “Molecules/Molecules online/Molecules annual” The researchers reviewed cepharanthine, a long-used bisbenzylisoquinoline alkaloid, for its antiviral properties, including significant inhibition of SARS-CoV-2. They discussed cepharanthine's other pharmacological actions, highlighted plasma membrane fluidity as a key antiviral mechanism, and examined its safety, bioavailability, and potential for new clinical applications.
6 citations
,
August 2024 in “Advanced Science” This study presents a Cu-catalyzed atroposelective method achieving high stereoselectivity for synthesizing chiral biaryl N-oxides, with product 3e showing promising therapeutic efficacy against triple-negative breast cancer in cell lines MDA-MB-231 and MDA-MB-468.
March 2024 in “Journal of Pharmaceutical and Sciences” This study investigated the phytochemical composition and antibacterial and antioxidant activities of Zaleya pentandra extracts, finding high total polyphenol and flavonoid content and significant antibacterial effects, particularly in acetone extract, which may be suitable for developing antibacterial agents.
3 citations
,
July 2018 in “Biomedicine & pharmacotherapy” This study suggests that paeoniflorin's protective effects on brain astrocytes may be mediated by TSPO and neurosteroids biosynthesis.
30 citations
,
January 2016 in “BioMed Research International” This study identified corilagin as a major antitumor component in Phyllanthus niruri, with broad-spectrum activity against cancer cells and high content in Dimocarpus longan.
14 citations
,
February 1994 in “Tetrahedron Letters” This study found that using anhydrous cerium(III) chloride with alkyl Grignard reagents significantly improved the addition to sterically hindered 17-ketosteroids, resulting in high yields and stereoselectivity.
6 citations
,
September 2024 in “BMC Pulmonary Medicine” This study demonstrated that CEP may effectively treat pulmonary fibrosis by inhibiting fibroblast activation through regulating macrophage M2 polarization and decreasing fibrosis-associated factors, suggesting a new avenue for future research in this area.
2 citations
,
March 1977 in “British Journal of Dermatology” This study found that intracutaneous injections of nandrolone phenylpropionate specifically induced local epidermal thickening and increased sebaceous gland volume in female hairless hamsters, independent of a dermal inflammatory response.
25 citations
,
May 2016 in “Molecular biology of the cell” This study found that the AtSfh1 protein in Arabidopsis is essential for phosphatidylinositol-4,5-bisphosphate signaling crucial to polarized root hair growth, utilizing both phosphatidylinositol and phosphatidylcholine-binding activities.
5 citations
,
February 1997 in “Bioorganic & Medicinal Chemistry” This study found that among 17 beta-(N-ureylene-N,N'-disubstituted)-4-azasteroids, those with an N'-phenyl moiety were the most effective inhibitors of human type I 5 alpha-reductase.
This chapter reviews various types of aromatic compounds and provides references, but reports no new experimental results.
53 citations
,
July 2021 in “International Journal of Molecular Sciences” This study found that extracts from Geranium pyrenaicum show promising antioxidant, enzyme inhibitory, and antiviral activities, particularly the methanolic extract's antiviral activity against HSV-1.
April 2019 in “Majalah Obat Tradisional” This study found that adding menthol to Phyllanthus niruri ethanol extract gel enhanced hair growth and thickness in rats.
This study found that four synthesized thiazolidinone derivatives showed potential anticancer activity against MCF7 and HeLa cell lines, suggesting their further investigation for anticancer drug development.
3 citations
,
May 2025 in “Plant Cell & Environment” This study found that in Arabidopsis, the CLE14 peptide regulates root hair growth by promoting elongation, an effect that requires CLV2 and CRN proteins and involves ethylene signalling along with hydrogen peroxide and nitric oxide pathways.
23 citations
,
October 2008 in “Journal of medicinal chemistry” This study suggests that PF-0998425 is an effective androgen receptor antagonist for sebum control and androgenetic alopecia with rapid metabolism reducing the risk of systemic side effects.
October 2021 in “Scholarworks (University of Massachusetts Amherst)” This dissertation demonstrates that FERONIA regulates essential plant functions such as RAC/ROP signaling, pollen tube reception, cell wall integrity, and sugar signaling as a cell surface receptor kinase.
August 2025 in “ACS Omega” This study synthesized and evaluated hydroxycinnamate derivatives for their ability to inhibit human SRD5A1, finding that three compounds showed significant inhibitory activity and low cytotoxicity. Compound 10a notably reduced SRD5A1 protein expression in cells, suggesting potential for nonsteroidal treatment of androgen-related conditions.
May 2022 in “Current Enzyme Inhibition” This study found that the synthesized compound 7b exhibited higher 5α-reductase inhibitory activity, increased solubility, and dissolution compared to finasteride, suggesting its potential as a lead compound for benign prostatic hyperplasia treatment.
August 2010 in “한국한의학연구원 논문집” In this animal study, Phellodendri Cortex extract reduced prostate tissue damage and inhibited 5α-reductase gene expression in rats with experimentally induced benign prostatic hyperplasia.
1 citations
,
July 2022 in “Plant Cell, Tissue and Organ Culture (PCTOC)” This study identified that the biosynthetic pathways for coumestans in Eclipta prostrata are derived from acetate and shikimate pathways, while phenylpropanoid biosynthesis is exclusively from the shikimate pathway.
This review explores the synthesis and potential of azasteroids as novel drugs, discussing challenges in their production and reporting no new clinical results.
9 citations
,
November 2012 in “Biomolecules & therapeutics” This study found that diphlorethohydroxycarmalol significantly increased prostaglandin $E_2$ synthesis in HaCaT human keratinocytes by upregulating COX-1 and COX-2 expression, suggesting potential benefits from elevated $PGE_2$ production.
2 citations
,
December 2008 in “Journal of Chemical Crystallography” This study reports the crystal structure and geometric parameters of a modified Finasteride derivative, highlighting significant differences in dihedral angles compared to its solvated analog and computational models.
17 citations
,
May 2014 in “Naunyn-Schmiedeberg's Archives of Pharmacology” In this study, 7-phloroeckol, derived from marine brown algae, was found to promote hair growth by increasing cell proliferation and hair shaft elongation in cultured human hair follicles.
January 2026 in “RSC Medicinal Chemistry” This study notes the ongoing challenge in developing new drugs for androgenetic alopecia, mentioning that both minoxidil and finasteride were originally intended for treating hypertension. Results are not reported.