Design and Synthesis of Novel Azasteroids and Pseudoazulenyl Nitrones

The dissertation from 6 years ago focused on the synthesis of azasteroids and pseudoazulenyl nitrones, two classes of compounds with potential pharmacological benefits. Azasteroids, modified steroids with one or more nitrogen atoms, have been shown to have a variety of biological activities without undesirable side effects. The research explored new synthetic methods for creating azasteroids, resulting in the design and synthesis of three tricyclic hydrazone compounds that mimic the tetracyclic rigid core structure of azasteroids. The second part of the research aimed at synthesizing cationic pseudoazulenyl nitrones with mitochondriotropic properties, using the natural compound valtrate. Although attempts to convert these compounds into cationic pseudoazulenyl nitrones failed, a pseudoazulenyl dinitrone molecule with an imidazole group and a pseudoazulenyl mono nitrone compound with an electron donating group were successfully synthesized.