Ultrasound-Assisted Facile Synthesis and Anticancer Evaluation of Novel N-(2-Substituted Phenyl-4-Oxathiazolidine-3-Carbonothioyl) Benzamide
November 2018
Studysummary This study found that four synthesized thiazolidinone derivatives showed potential anticancer activity against MCF7 and HeLa cell lines, suggesting their further investigation for anticancer drug development.
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In 2018, researchers synthesized ten novel derivatives of N-(2-substituted phenyl)- 4-oxothiazolidine-3-carbonothioyl benzamide derivatives using an eco-friendly synthetic route involving ultrasound. These compounds, which contain nitrogen and sulfur in a heterocycle known as thiazolidinone, were found to have varied biological activities. When coupled with benzamide, the anticancer activity of these derivatives was enhanced. Specifically, derivatives 6a and 6c showed potential activity against the MCF7 cell line, while 6d and 6h exhibited potential activity against both the MCF7 and HeLa cell lines. The researchers suggested that these derivatives, due to their good anticancer activity, could be further studied and modified for the development of anticancer drugs. The structures of the synthesized compounds were confirmed through spectral characterization.
