July 2025 in “Phytomedicine Plus” This study reported that Cyperus rotundus L., a plant used in traditional medicine, effectively reduces hair growth with minimal side effects, showing efficacy comparable to Alexandrite laser treatments in certain cases, particularly for white hair, positioning it as a potential natural alternative to chemical depilatories.
1 citations
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November 2024 in “Life” In this study, Desmodesmus pannonicus water extract demonstrated significant antioxidative properties, inhibited melanin production, promoted wound healing in human keratinocyte cells, and showed potential for hair growth enhancement in human follicle dermal papilla cells, suggesting its promise for future dermatological applications.
January 2025 in “Figshare” In this case study, a 17-month-old girl experienced sudden hair depigmentation during septic shock hospitalization, suggesting systemic stress as a potential trigger for pediatric canities subita associated with diffuse alopecia areata.
July 2026 in “International Journal of Drug Delivery Technology” This study evaluated a Piper betle leaf emulgel for topical use and found it to have good stability, non-irritant properties, and significant hair growth activity in albino mice, suggesting its potential for dermatological and hair growth applications.
101 citations
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April 2013 in “Science” This study describes how feather pigmentation in birds is regulated by melanocyte distribution, differentiation, and patterned agouti expression, contributing to diverse and adaptive color patterns.
November 2017 in “The Philippine journal of veterinary medicine/Philippine Journal of Veterinary Medicine” This study found that aquapuncture analgesia using chili pepper decoction resulted in more complete wound healing and increased hair growth compared to distal paravertebral nerve block in goats after exploratory laparotomy.
September 2025 in “ACS Applied Materials & Interfaces” The researchers reported that a newly developed photo-cross-linked hydrogel with multifunctional properties, including antimicrobial and antioxidant effects, significantly improved diabetic wound healing, achieving over 90% wound closure in seven days in vivo.
October 2020 in “Ayurline: international journal of research in indian medicine” This review investigates the causes of greying hair in children, but reports no new clinical findings.
16 citations
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February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
10 citations
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October 2019 in “Acta Pharmaceutica” This review discusses the use of herbal medicinal products for treating chronic skin diseases like vitiligo and psoriasis and reports no new clinical results; the authors emphasize the need for standardized extracts and further research.
3 citations
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February 1943 in “The American journal of digestive diseases/American journal of digestive diseases” Riboflavin helps heal bed sores, inositol aids skin diseases, and calcium pantothenate doesn't prevent gray hair.
November 2024 in “Majalah Farmasetika” In this study, the researchers explored a hair dye gel formulated with Indonesian native plant extracts and found it produced stable brown shades on bleached hair, with the most preferred dark brown achieved at a 12% concentration, and showed no skin irritation.
January 2023 in “Indian Dermatology Online Journal” This article reviews the indications for micropigmentation in dermatological conditions like stable vitiligo and alopecia, but presents no new clinical results.
7 citations
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January 2025 in “Current Issues in Molecular Biology” This study found that PDRN derived from Lactobacillus rhamnosus showed superior antioxidant and wound-healing properties compared to salmon-derived PDRN, while also offering potential benefits in immune modulation and bioavailability.
7 citations
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January 2021 in “Evidence-based complementary and alternative medicine” This study suggests that porphyra-334 may have antiaging properties, promoting collagen synthesis, improving periorbital wrinkles, and supporting hair follicle growth through gene regulation.
39 citations
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March 2017 in “Dermatologic clinics” This article reviews the process of repigmentation in vitiligo and emphasizes the role of UV light as the most potent stimulus, with no new clinical findings reported.
50 citations
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October 1918 in “The journal of experimental zoology” Artificially inducing hair regrowth in mice can change the normal pattern and timing of hair growth, with minimal color differences between old and new fur.
1 citations
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July 2025 in “Cosmetics” This review highlights the multifunctional benefits of plant-derived ingredients in skincare, such as antioxidant and anti-inflammatory effects, supported by biological evidence from medicinal plants like Camellia sinensis and Panax ginseng, suggesting their potential as natural dermocosmetic agents.
October 2024 in “Věda a perspektivy” This study found that permanent makeup, or micropigmentation, effectively masks post-surgical cleft lip scars and corrects lip asymmetry, providing aesthetic and psychological benefits such as improved self-esteem and reduced social anxiety, contributing to better social integration for patients.
13 citations
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July 2011 in “Photomedicine and laser surgery” This study found that coloring white facial hair is an effective and feasible adjunct to intense pulsed light therapy for hair removal, with similar efficacy between using black eyeliner and black hair dye.
December 2025 in “Journal of Ayurveda and Integrated Medical Sciences” This article discusses the ancient Ayurvedic explanations of premature greying, or Akala Palitya, highlighting how modern lifestyle factors like stress and pollution have increased its prevalence, particularly in urban and developing areas.
January 2023 in “Health science reports” In this study, oral Pycnogenol® intake was reported to significantly increase hair density and improve scalp microcirculation in Han Chinese menopausal women over six months.
January 2026 in “Frontiers in Medicine” In this study, PP-PTKL exhibited antioxidant, anti-inflammatory, and pro-melanogenic effects in laboratory settings, suggesting its potential role in preventing or treating hair greying. Further animal and human studies are needed to verify these findings.
4 citations
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April 2022 in “Microorganisms” In this study, clinically used preoperative skin preparations with povidone iodine and chlorhexidine gluconate did not meet FDA log-reduction standards for bacterial bioburden in a porcine model, suggesting persistent infection risks.
10 citations
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January 2016 in “ACG Case Reports Journal” This case report describes a 73-year-old male with numerous colon polyps whose long-term use of Cape Aloe likely caused melanosis coli, which helped highlight the polyps' locations.
3 citations
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April 2015 in “International research journal of pharmacy” This study concluded that the follicular route is a significant pathway for delivering gentamicin through the skin, as demonstrated by higher drug permeation in non-plugged pig's ear skin compared to plugged skin.
April 2023 in “Pharmacognosy Magazine” In a study using a mouse model, Cerasus serrulata flower extracts significantly increased β-catenin and VEGF expression, promoting hair blackening and suggesting potential as a treatment for premature greying.
2 citations
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June 2020 in “Dermatology and therapy” In this case report, narrowband-UVB phototherapy successfully treated a rare instance of Graham Little-Piccardi-Lassueur syndrome, a variant of lichen planopilaris, as investigated through non-invasive imaging techniques.
5 citations
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January 2010 in “Medicinal Plants - International Journal of Phytomedicines and Related Industries” This review discusses the diverse pharmacological activities of T. procumbens, such as hypotensive and hair growth-promoting effects, but reports no new clinical findings.
April 2022 in “International journal of green and herbal chemistry” This article discusses the green synthesis of silver nanomaterials using Tridax procumbens and reports no new clinical findings.