Photo-Cross-Linked and Photothermal Flammulina Velutipes Polysaccharide Hydrogel Loaded with Caffeic Acid-Copper Nanozyme for Diabetic Wound Healing

    September 2025 in “ ACS Applied Materials & Interfaces ”
    Meimei Fu, Qianru Xiang, Zhuoyi Huang, Wenjun Luo, Zhou Fang, Jintao Li, Yue Li, Zijun Xia, Yina Huang, Yitao Zhao, Wenzhen Liao, Jinshan Guo
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    TLDR The hydrogel effectively heals diabetic wounds, closing over 90% within 7 days.
    The study presents a novel photo-cross-linked Flammulina velutipes polysaccharide hydrogel loaded with caffeic acid-copper nanozyme (FVP@CCN) for diabetic wound healing. This hydrogel exhibits rapid degradability, tunable mechanical properties, and significant antimicrobial activity. The incorporated nanozyme enhances photothermal-induced antimicrobial ability, ROS scavenging, and angiogenesis promotion. In vivo studies demonstrated that FVP@CCN effectively addresses multiple healing impairments in diabetic wounds, achieving over 90% wound closure within 7 days. The hydrogel also promotes hemostasis, sustainable antibacterial, antioxidant, anti-inflammatory effects, cell proliferation, and hair follicle regeneration, indicating its significant potential for diabetic wound treatment.
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