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Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Taking oral testosterone with finasteride or dutasteride doubles testosterone levels, and food slightly affects it.

Finasteride blocks progesterone's effect on absence seizures in rats.

Researchers created a skin patch that delivers two drugs for treating enlarged prostate, which may improve patient use and dosage control.

Plant-based treatments can effectively and safely treat hair loss.

Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.

Activating TSPO helps protect the retina from damage caused by high eye pressure in glaucoma.

Saw palmetto helps with nighttime urination and urine flow, similar to finasteride.

Dutasteride injections can help hair growth in androgenic alopecia but need more research for long-term use.

Avicennia marina extract and avicequinone C can potentially promote hair growth and treat hair loss by interfering with hair loss mechanisms and boosting growth factors.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Finasteride helps protect brain in old male rats.

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

Men over 66 taking medication for prostate enlargement have a higher risk of depression and self-harm, especially in the first 18 months of treatment.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

Antidepressants, 5α-reductase inhibitors, and isotretinoin can cause long-lasting sexual dysfunction.

Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.

Flutamide improves female hair loss when other treatments fail, but may cause liver toxicity.

A new compound effectively inhibits human 5α-reductase 1.

Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Finasteride may affect PNMT, causing side effects.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.