Uses of Spironolactone as an Antiandrogenic Drug

January 2024 in “ La Ciencia al Servicio de la Salud y Nutrición ”

Rolando Teruel Ginés, María de los Ángeles Leyva Montero, Gerzon Yaír Calle Álvarez, I. Valverde, Krishna Mara Rodrigues Freire

spironolactone antiandrogenic androgenic alopecia hirsutism acne peripheral androgen receptors 5α-reductase 17α-hydroxylase 17,20-lyase Aldactone

TLDR Spironolactone is effective and safe for treating hair loss, excessive hair growth, and acne.

The review highlights spironolactone's antiandrogenic properties, making it effective for treating dermatological conditions like androgenic alopecia, hirsutism, and acne by inhibiting peripheral androgen receptors and enzymes such as 5α-reductase, 17α-hydroxylase, and 17,20-lyase. The study utilized 33 relevant references from 46 sources, including books and scientific articles. Spironolactone is deemed safe and effective, either as monotherapy or in combination with other drugs, but attention must be given to its adverse effects and contraindications.

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