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Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.

Treatment during development affects hormone balance and sexual behavior in male rats.

New compounds may soon be tested to treat excessive hair growth in women.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Finasteride safely lowers DHT levels without affecting testosterone.

Androgens, like testosterone, are crucial for early testicular descent in rats.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

People with hair loss may have different levels of certain hormones due to changes in hormone processing.

DHEA acts like a male hormone on rat skin glands and doesn't turn into female hormones there.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.

The document concludes that more multidisciplinary research is needed to understand and treat PCOS, a condition that significantly affects women's health and quality of life.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride affects prostate weights and pituitary activity differently with age.

Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Proscar (finasteride) blocks 5α-reductase in sea urchin ovaries and testes, suggesting potential treatment for androgen-related conditions.

Ganoderma lucidum, a type of mushroom, may help treat enlarged prostate by blocking testosterone conversion.

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

Finasteride effectively treats enlarged prostate and male baldness, improves symptoms of hirsutism in women, but doesn't work for acne, and may delay prostate cancer progression with few side effects.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

The modified Ferriman-Gallwey method is a useful tool for diagnosing hirsutism.