Exclusive Androgenic Effect of Dehydroepiandrosterone in Sebaceous Glands of Rat Skin

    August 2000 in “ Journal of Endocrinology ”
    Antigone Sourla, Virgile Richard, Fernand Labrie, Claude Labrie
    Studysummary In this study, treatment with DHEA induced mild to moderate hyperplasia of sebaceous glands in ovariectomized rats, which was prevented by the antiandrogen Flutamide but not by the antiestrogen EM-800.
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    Research cited in this study 7

    1. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    2. Localization and Regulation of Expression of the FAR-17A Gene in the Hamster Flank Organs Journal of Investigative Dermatology · 1996
    3. Adrenal Steroid Precursors Exert Potent Androgenic Action in the Hamster Sebaceous Glands of Flank Organs and Ears Endocrinology · 1996
    4. Additive In Vivo Growth-Inhibitory Effects of Flutamide and Finasteride on Androgen-Sensitive Shionogi 115 Carcinoma Endocrine-related Cancer · 1996
    5. Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp Journal of Endocrinology/Journal of endocrinology · 1992
    6. Elevated Free Testosterone Levels in Women With Acne Archives of Dermatology · 1983
    7. Metabolism and Action of Androgen in the Skin International Journal of Dermatology · 1979

    Related research 1

    1. Exclusive Androgenic Effect of Dehydroepiandrosterone in Sebaceous Glands of Rat Skin Journal of Endocrinology · 2000