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In this study, treatment with DHEA induced mild to moderate hyperplasia of sebaceous glands in ovariectomized rats, which was prevented by the antiandrogen Flutamide but not by the antiestrogen EM-800.

This study found that the androgen precursors DHEA and androstenedione stimulated androgen-sensitive parameters in the sebaceous glands of the skin in castrated male hamsters.

This study found that distinct isoenzymes of 3 beta-hydroxysteroid dehydrogenase are expressed in human adrenals and gonads compared to the placenta and skin.

This review discusses hormone replacement therapy for menopausal women, emphasizing DHEA's unique ability to convert into sex steroids only in targeted tissues, and reports no new clinical results.

This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.